The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope

Louise Mercer¹, Abhishek Abhishek^{2

3}, Akhila Kavirayani⁴, Alison Ahmed⁵, Alan Davidson⁶, Amy Foulkes⁷, Claire Jones⁸, Clare Nash⁹, Emily Rose-Parfitt¹⁰, Emmandeep Dhillon¹¹, Genevieve Zabate¹², Helen Twohig¹³, Hope De Vere¹⁴, Jennifer Scott¹⁵, John Reynolds¹⁶, Julia Holmes¹⁷, Karen Hartley¹⁸, Kishore Warrier¹⁹, Kataryzna Nowak²⁰, Kate Parsons²¹, Katie Bechman²², Lisa Bray²³, Madura Adikari²⁴, Natasha Wood²⁵, Nicola Faithfull²⁶, Nicola Gullick²⁷, Pratyasha Saha²⁸, Rebecca Heaton²⁹, Samundeeswari Deepak³⁰, Samantha Hider^{13

31}, Sameena Khalid³², Sanaa Suleiman Said³³, Sarah Ryan³⁴, Stuart Kyle³⁵, Subhra Raghuvanshi³⁶, Su-Yin Tan³⁷, Vinay Shivamurthy³⁸, James Galloway²²

Affiliations

¹ Department of Rheumatology, Stepping Hill Hospital, Stockport NHS Foundation Trust, Stockport, UK.
² Academic Rheumatology, City Hospital Nottingham, University of Nottingham, Nottingham, UK.
³ Nottingham NIHR BRC, Nottingham, UK.
⁴ Paediatric Rheumatology, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
⁵ Department of Rheumatology, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-Under-Lyme, UK.
⁶ Community Rheumatology, Modality LLP, Birmingham, UK.
⁷ Department of Dermatopharmacology, Salford Royal NHS Foundation Trust, Salford, UK.
⁸ Medicines Management, Powys Teaching Health Board, Brecon, Powys, UK.
⁹ Pharmacy Department, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
¹⁰ Department of Rheumatology, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.
¹¹ Department of Rheumatology, New Cross Hospital, Royal Wolverhampton NHS Trust, Wolverhampton, UK.
¹² Rheumatic Diseases Unit, Western General Hospital NHS Lothian, Edinburgh, UK.
¹³ School of Medicine, Keele University, Keele, UK.
¹⁴ Department of Rheumatology, Gloucestershire Hospitals NHS Foundation Trust, UK.
¹⁵ Department of Hepatology and Gastroenterology, Stepping Hill Hospital, Stockport NHS Foundation Trust, Stockport, UK.
¹⁶ Institute of Inflammation and Ageing, University of Birmingham Research Labs, Queen Elizabeth Hospital, University of Birmingham, Birmingham, UK.
¹⁷ Expert by Experience, Versus Arthritis Fellowship Expert Committee Member.
¹⁸ Department of Pharmacy, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.
¹⁹ Paediatric and Adolescent Rheumatology, Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
²⁰ Department of Rheumatology, Belfast Health and Social Care Trust, Belfast, UK.
²¹ Expert by Experience, UK.
²² Centre for Rheumatic Diseases, King's College London, London, UK.
²³ Department of Paediatrics, St Richard's Hospital, Chichester, UK.
²⁴ Department of Rheumatology, Rotherham General Hospital, Rotherham NHS Foundation Trust, Rotherham, UK.
²⁵ Brannam Medical Centre, Barnstaple, UK.
²⁶ Childhood Arthritis and Rheumatic Diseases Unit, Birmingham Children's Hospital, Birmingham, UK.
²⁷ Department of Rheumatology, University Hospitals Coventry & Warwickshire, Coventry, UK.
²⁸ Department of Rheumatology, Norfolk and Norwich University Hospital, Norfolk, UK.
²⁹ Department of Rheumatology, Stockport NHS Foundation Trust, Stockport, UK.
³⁰ Paediatric & Adolescent Rheumatology, Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
³¹ Department of Rheumatology, Haywood Hospital, Midlands Partnership Foundation Trust, Stoke-on-Trent, UK.
³² Rheumatology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK.
³³ Department of Internal Medicine, State University of Zanzibar, Tunguu, Zanzibar, Tanzania.
³⁴ Department of Rheumatology, Midlands Partnership University NHS Foundation Trust, Stoke-on-Trent, UK.
³⁵ Department of Rheumatology, North Devon District Hospital, Royal Devon University, Devon, UK.
³⁶ Department of Rheumatology, Wrexham Maelor Hospital, Betsi Cadawaladr University Hospital, Wrexham, UK.
³⁷ Department of Rheumatology, NHS Tayside, Dundee, UK.
³⁸ Department of Rheumatology, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.

PMID: 39006537
PMCID: PMC11239329
DOI: 10.1093/rap/rkae077

Review

The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope

Louise Mercer et al. Rheumatol Adv Pract. 2024.

. 2024 Jul 12;8(3):rkae077.

doi: 10.1093/rap/rkae077. eCollection 2024.

Authors

Affiliations

¹ Department of Rheumatology, Stepping Hill Hospital, Stockport NHS Foundation Trust, Stockport, UK.
² Academic Rheumatology, City Hospital Nottingham, University of Nottingham, Nottingham, UK.
³ Nottingham NIHR BRC, Nottingham, UK.
⁴ Paediatric Rheumatology, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
⁵ Department of Rheumatology, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-Under-Lyme, UK.
⁶ Community Rheumatology, Modality LLP, Birmingham, UK.
⁷ Department of Dermatopharmacology, Salford Royal NHS Foundation Trust, Salford, UK.
⁸ Medicines Management, Powys Teaching Health Board, Brecon, Powys, UK.
⁹ Pharmacy Department, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
¹⁰ Department of Rheumatology, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.
¹¹ Department of Rheumatology, New Cross Hospital, Royal Wolverhampton NHS Trust, Wolverhampton, UK.
¹² Rheumatic Diseases Unit, Western General Hospital NHS Lothian, Edinburgh, UK.
¹³ School of Medicine, Keele University, Keele, UK.
¹⁴ Department of Rheumatology, Gloucestershire Hospitals NHS Foundation Trust, UK.
¹⁵ Department of Hepatology and Gastroenterology, Stepping Hill Hospital, Stockport NHS Foundation Trust, Stockport, UK.
¹⁶ Institute of Inflammation and Ageing, University of Birmingham Research Labs, Queen Elizabeth Hospital, University of Birmingham, Birmingham, UK.
¹⁷ Expert by Experience, Versus Arthritis Fellowship Expert Committee Member.
¹⁸ Department of Pharmacy, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.
¹⁹ Paediatric and Adolescent Rheumatology, Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
²⁰ Department of Rheumatology, Belfast Health and Social Care Trust, Belfast, UK.
²¹ Expert by Experience, UK.
²² Centre for Rheumatic Diseases, King's College London, London, UK.
²³ Department of Paediatrics, St Richard's Hospital, Chichester, UK.
²⁴ Department of Rheumatology, Rotherham General Hospital, Rotherham NHS Foundation Trust, Rotherham, UK.
²⁵ Brannam Medical Centre, Barnstaple, UK.
²⁶ Childhood Arthritis and Rheumatic Diseases Unit, Birmingham Children's Hospital, Birmingham, UK.
²⁷ Department of Rheumatology, University Hospitals Coventry & Warwickshire, Coventry, UK.
²⁸ Department of Rheumatology, Norfolk and Norwich University Hospital, Norfolk, UK.
²⁹ Department of Rheumatology, Stockport NHS Foundation Trust, Stockport, UK.
³⁰ Paediatric & Adolescent Rheumatology, Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
³¹ Department of Rheumatology, Haywood Hospital, Midlands Partnership Foundation Trust, Stoke-on-Trent, UK.
³² Rheumatology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK.
³³ Department of Internal Medicine, State University of Zanzibar, Tunguu, Zanzibar, Tanzania.
³⁴ Department of Rheumatology, Midlands Partnership University NHS Foundation Trust, Stoke-on-Trent, UK.
³⁵ Department of Rheumatology, North Devon District Hospital, Royal Devon University, Devon, UK.
³⁶ Department of Rheumatology, Wrexham Maelor Hospital, Betsi Cadawaladr University Hospital, Wrexham, UK.
³⁷ Department of Rheumatology, NHS Tayside, Dundee, UK.
³⁸ Department of Rheumatology, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.

PMID: 39006537
PMCID: PMC11239329
DOI: 10.1093/rap/rkae077

Abstract

This guideline will provide up-to-date, evidence-based recommendations on the safe use of non-biologic DMARDs, also called conventional synthetic DMARDs (csDMARD), across the full spectrum of autoimmune rheumatic diseases. The guideline will update the guideline published in 2017 and will be expanded to include people of all ages. Updated information on the monitoring of DMARDs and vaccinations will be included. The guideline will be developed using the methods and processes described in the British Society for Rheumatology's 'Creating clinical guidelines: our protocol', updated 2023.

Keywords: DMARD management guideline.

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References

1. Ledingham J, Gullick N, Irving K et al. BSR and BHPR guideline for the prescription and monitoring of non-biologic disease-modifying anti-rheumatic drugs. Rheumatology (Oxford) 2017;56:865–8. - PubMed
1. British Society for Rheumatology. Creating clinical guidelines: our protocol v.5.4, revised on behalf of SAGWG, updated 2023. https://www.rheumatology.org.uk/Portals/0/Documents/Guidelines/Guideline... (26 June 2024, date last accessed).
1. Nakafero G, Grainge MJ, Card T et al. Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum. Rheumatology (Oxford) 2022;61:2783–91. - PMC - PubMed
1. Nakafero G, Card T, Grainge MJ et al. Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and health economic evaluation. EClinicalMedicine 2023;64:102213. - PMC - PubMed
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The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope

Affiliations

The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope

Authors

Affiliations

Abstract

References

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LinkOut - more resources

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