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. 2024 Jul 11;19(1):20240996.
doi: 10.1515/med-2024-0996. eCollection 2024.

Evaluating anemia in HIV-infected patients using chest CT

Le Zhang  1 , Yan Bi  2 , Min Qi  3 , Xu-Wen Fu  3 , Jia-Lu Wei  3 , Wei Gan  3 , Long Zhu  3 , Xiang Li  3 , Jin-Song Bai  4
Affiliations

Evaluating anemia in HIV-infected patients using chest CT

Le Zhang et al. Open Med (Wars). .

Abstract

Objective: The aim of this study was to investigate the role of the Hounsfield unit value of chest CT non-contrast enhanced scan in evaluating the severity of anemia in HIV-infected patients.

Methods: Patients with HIV infection combined with anemia admitted to the Kunming Third People's Hospital were retrospectively collected and divided into mild anemia, moderate anemia, and severe anemia groups by peripheral hemoglobin (HB) content and calculated the ratio of ventricular septum density (VSD) to left ventricular density (LVD) and VSD to right ventricular density (RVD); then, the above patients were divided into the critical value group and the non-critical value group according to HB and compared the differences of LVD, RVD, VSD/LVD, and VSD/RVD in the two groups of patients.

Results: A total of 126 patients were included, with a mean age of 47.9 ± 11.1 years; 43 cases were in the mild anemia group, 59 cases were in the moderate anemia group, and 24 cases were in the severe anemia group; the differences in LVD, RVD, VSD/LVD, and VSD/RVD were significant in the three groups; VSD/LVD was an independent predictor for the diagnosis of anemia critical value in the non-critical value group vs critical value group by multifactorial binary logistic regression analysis, and the ROC was plotted using VSD/LVD with an area under the curve of 0.731.

Conclusions: The measurement of cardiac cavity density and ventricular septal density under CT plain film scan has a high accuracy in evaluating the severity of anemia in patients with HIV infection and can quickly determine the severity of HIV infection in the early stage and treat it as soon as possible.

Keywords: HIV; anemia; computed tomography.

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Conflict of interest statement

Conflict of interest: The authors of this study declared no conflict of interest.

Figures

Figure 1
Figure 1
Chest CT images of a HIV-infected patient with anemia (1) A male patient, 44 years old, with mild anemia, HB = 109 g/L, LVD and RVD slightly lower than VSD; (2) A female patient, 42 years old, with moderate anemia, HB = 77 g/L, LVD and RVD lower than VSD; (3) A male patient, 46 years old, with severe anemia, HB = 40 g/L, LVD and RVD significantly lower than VSD.
Figure 2
Figure 2
ROC curve of discriminating critical value by probability value of regression equation. (a) ROC curve of LV; (b) ROC curve of VSD/LV.
See this image and copyright information in PMC

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