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. 2024 Nov;96(5):1020-1025.
doi: 10.1002/ana.27033. Epub 2024 Jul 15.

Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology

Silvia Falso  1 , Marco Gessi  2 , Sofia Marini  1 , Roberta Benvenuto  2 , Eleonora Sabatelli  3 , Antonio D'Amati  4 , Martina Marini  1 , Amelia Evoli  1   3 , Raffaele Iorio  1   3
Affiliations

Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology

Silvia Falso et al. Ann Neurol. 2024 Nov.

Abstract

Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8%). Patients with cancer were significantly older at time of MuSK-MG onset. ANN NEUROL 2024;96:1020-1025.

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Conflict of interest statement

Potential Conflicts of Interest

The authors declare that they have no potential conflict of interest.

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