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. 2024 Oct;39(10):1873-1877.
doi: 10.1002/mds.29928. Epub 2024 Jul 15.

Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease

Saar Kariv  1 , Jeong Woo Choi  1 , Koorosh Mirpour  1 , Ann M Gordon  2 , Amirreza Alijanpourotaghsara  1 , Mohsen Benam  1 , Ruwayd Abdalla  1 , Sahil Chilukuri  1 , Jianwen W Gu  3 , Hemant Bokil  3 , Shruti Nanivadekar  4   5 , Aryn H Gittis  4   6 , Nader Pouratian  1
Affiliations

Pilot Study of Acute Behavioral Effects of Pallidal Burst Stimulation in Parkinson's Disease

Saar Kariv et al. Mov Disord. 2024 Oct.

Abstract

Background: Burst-patterned pallidal deep brain stimulation (DBS) in an animal model of Parkinson's disease (PD) yields significantly prolonged therapeutic benefit compared to conventional continuous DBS, but its value in patients remains unclear.

Objectives: The aims were to evaluate the safety and tolerability of acute (<2 hours) burst DBS in PD patients and to evaluate preliminary clinical effectiveness relative to conventional DBS.

Methods: Six PD patients were studied with DBS OFF, conventional DBS, and burst DBS. Unified Parkinson's Disease Rating Scale III (UPDRS-III) and proactive inhibition (using stop-signal task) were evaluated for each condition.

Results: Burst and conventional DBS were equally tolerated without significant adverse events. Both stimulation patterns provided equivalent significant UPDRS-III reduction and increased proactive inhibition relative to DBS OFF.

Conclusions: This pilot study supports the safety and tolerability of burst DBS, with acute effects similar to conventional DBS. Further larger-scale studies are warranted given the potential benefits of burst DBS due to decreased total energy delivery. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keywords: Parkinson's disease; burst stimulation; deep brain stimulation.

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Conflict of interest statement

Relevant conflicts of interest/financial disclosures: S.K., J.W.C., K.M., A.M.G., A.A., M.B., R.A., and S.C.: none. W.G.: employment: Boston Scientific; ownership of Boston Scientific stock. H.B.: employment: Boston Scientific; ownership of Boston Scientific stock. S.N., A.H.G., and N.P.: none.

Figures

FIG. 1.
FIG. 1.
(A) Experimental procedure. (B) Schematic description of burst DBS (deep brain stimulation) protocol. (C) Schematic description of stop-signal task (SST). Comparisons of (D) motor symptoms and (E) proactive inhibition during SST across therapeutic conditions (Conv: conventional DBS, Burst: burst DBS, *P < 0.05, ns: nonsignificant).
See this image and copyright information in PMC

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