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. 2024 Oct;21(10):e202401210.
doi: 10.1002/cbdv.202401210. Epub 2024 Sep 19.

Hypolipidemic Effects of Mesona chinensis Benth Polysaccharides with Different Structures and Molecular Weights

Jia-Lin Du  1   2   3 , Lu-Hua Xiao  1   2   3 , Jie-Hui Yang  1   2   3 , Qing Luo  1   2   3 , Jing-Wen Li  1   2   3 , Ying-Shan Feng  1   2   3 , Ruo-Ting Zhan  1   2   3 , Ping Yan  1   2   3
Affiliations

Hypolipidemic Effects of Mesona chinensis Benth Polysaccharides with Different Structures and Molecular Weights

Jia-Lin Du et al. Chem Biodivers. 2024 Oct.

Abstract

Four novel Mesona chinensis Benth polysaccharides were isolated using aqueous alcohol precipitation. Their molecular weights were determined using high-performance gel permeation chromatography: MA1 (2.3 kDa), MA2 (80.5 kDa), MA3 (180.9 kDa), and MA4 (635.2 kDa), and their compositions were analyzed using GC-MS. The polysaccharides were mainly D-glucose, D-galactose, L-Rhamnose, D-arabinose, D-xylose, and D-mannose. The structural characteristics were further analyzed using infrared spectrophotometry and were identified as a type of pyrrhic sugar. An insulin-induced insulin resistance model of HepG2 cells and oleic acid-induced fat accumulation model of insulin were established to evaluate the hypolipidemic effects. Three Bacteroides spp. [Bacteroides thetaiotaomicron (BT), B. ovatus (BO), and B. cellulosilyticus (BC)] that were negatively correlated with lipid-lowering activity were used to evaluate the lipid-lowering activity of polysaccharides. The Bacteroides metabolites of MA1 and MA2 exhibited hypolipidemic effects and antioxidant activities and could potentially be used as lipid-lowering supplements.

Keywords: Bacteroides; Bioactivity; Mesona chinensis Benth; Polysaccharides; Structural.

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