Executive Summary-Society of Critical Care Medicine Guideline and American Society of Health-System Pharmacists for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults

Robert MacLaren¹, Joanna C Dionne², Anders Granholm³, Waleed Alhazzani^{2

4}, Paul M Szumita⁵, Keith Olsen⁶, Jeffrey F Barletta⁷, Morten Hylander Møller³, Constantine J Karvellas⁸, Paul Wischmeyer⁹, Ashley DePriest¹⁰, Victor Carlos¹¹, Debora Argetsinger¹², John J Carothers¹³, Rosemary Lee¹⁴, Lena Napolitano¹⁵, Dan Perri^{2

16}, Douglas F Naylor¹⁷

Affiliations

¹ Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO.
² Division of Gastroenterology and Critical Care Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada.
³ Department of Intensive Care, Righospitalet, University of Copenhagen, Copenhagen, Denmark.
⁴ Division of Critical Care, Department of Medicine, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
⁵ Department of Pharmacy Services, Brigham and Women's Hospital, Boston, MA.
⁶ Department of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE.
⁷ Department of Pharmacy Practice, Midwestern University College of Pharmacy, Glendale, AZ.
⁸ Division of Gastroenterology (Liver Unit), Department of Critical Care Medicine University of Alberta, Edmonton, AB, Canada.
⁹ Department of Anesthesiology and Surgery, Duke University Medical Center, Durham, NC.
¹⁰ Department of Food and Nutrition, Emory Healthcare, Atlanta, GA.
¹¹ Patient representative, Denver, CO.
¹² Neurology, University of Michigan Health-West, Wyoming, MI.
¹³ Department of Inpatient Pharmacy, United States Public Health Service, Alaska Native Medical Center, Anchorage, AK.
¹⁴ Critical Care and Progressive Care Units, Baptist Health South Florida, Miami, FL.
¹⁵ Acute Care Surgery, Surgical Critical Care, Department of Surgery, University of Michigan Health System, Ann Arbor, MI.
¹⁶ Divisions of Clinical Pharmacology & Toxicology and Critical Care Medicine, Department of Medicine, McMaster University, Hamiton, ON, Canada.
¹⁷ Department of Surgery-Trauma Surgery, Critical Care, and Acute Care Surgery, University Hospitals of Cleveland, Cleveland, OH.

PMID: 39007570
DOI: 10.1097/CCM.0000000000006329

Practice Guideline

Executive Summary-Society of Critical Care Medicine Guideline and American Society of Health-System Pharmacists for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults

Robert MacLaren et al. Crit Care Med. 2024.

. 2024 Aug 1;52(8):1295-1299.

doi: 10.1097/CCM.0000000000006329. Epub 2024 Jul 15.

Authors

Affiliations

¹ Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO.
² Division of Gastroenterology and Critical Care Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada.
³ Department of Intensive Care, Righospitalet, University of Copenhagen, Copenhagen, Denmark.
⁴ Division of Critical Care, Department of Medicine, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
⁵ Department of Pharmacy Services, Brigham and Women's Hospital, Boston, MA.
⁶ Department of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE.
⁷ Department of Pharmacy Practice, Midwestern University College of Pharmacy, Glendale, AZ.
⁸ Division of Gastroenterology (Liver Unit), Department of Critical Care Medicine University of Alberta, Edmonton, AB, Canada.
⁹ Department of Anesthesiology and Surgery, Duke University Medical Center, Durham, NC.
¹⁰ Department of Food and Nutrition, Emory Healthcare, Atlanta, GA.
¹¹ Patient representative, Denver, CO.
¹² Neurology, University of Michigan Health-West, Wyoming, MI.
¹³ Department of Inpatient Pharmacy, United States Public Health Service, Alaska Native Medical Center, Anchorage, AK.
¹⁴ Critical Care and Progressive Care Units, Baptist Health South Florida, Miami, FL.
¹⁵ Acute Care Surgery, Surgical Critical Care, Department of Surgery, University of Michigan Health System, Ann Arbor, MI.
¹⁶ Divisions of Clinical Pharmacology & Toxicology and Critical Care Medicine, Department of Medicine, McMaster University, Hamiton, ON, Canada.
¹⁷ Department of Surgery-Trauma Surgery, Critical Care, and Acute Care Surgery, University Hospitals of Cleveland, Cleveland, OH.

PMID: 39007570
DOI: 10.1097/CCM.0000000000006329

Erratum in

Executive Summary-Society of Critical Care Medicine Guideline and American Society of Health-System Pharmacists for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults: Erratum.
MacLaren R, Dionne JC, Granholm A, Alhazzani W, Szumita PM, Olsen K, Barletta JF, Hylander Møller M, Karvellas CJ, Paul W, Ashley D, Victor C, Argetsinger D, Carothers JJ, Lee R, Napolitano L, Perri D, Naylor DF. MacLaren R, et al. Crit Care Med. 2025 Jun 1;53(6):e1350. doi: 10.1097/CCM.0000000000006683. Epub 2025 Apr 24. Crit Care Med. 2025. PMID: 40272225 No abstract available.

No abstract available

PubMed Disclaimer

Conflict of interest statement

Dr. Szumita received funding from Trevena. Dr. Barletta received funding from Wolters Kluwer and Lexicomp. Dr. DePriest received funding from Baxter Channel One. Dr. Wischmeyer received funding from Abbott, Baxter, Fresenius Kabi Deutschland GmbH, Danone and Nutricia, Musclesound, Dutch State Mines, and Nestle. Dr. Argetsinger disclosed that she is an employee of the University of Michigan Health West and Bronson Methodist Hospital and Georgetown University School of Nursing. Dr. Dionne received funding from the Canadian Institutes of Health Research. Dr. Granholm received funding from Sygeforsikringen “Danmark.” The remaining authors have disclosed that they do not have any potential conflicts of interest.

References

1. Preslaski CR, Mueller SW, Kiser TH, et al.: A survey of prescriber perceptions about the prevention of stress-related mucosal bleeding in the intensive care unit. J Clin Pharm Ther. 2014; 39:658–662
1. Barletta JF, Kanji S, MacLaren R, et al.; American-Canadian consortium for Intensive Care Drug Utilization (ACID) Investigators: Pharmacoepidemiology of stress ulcer prophylaxis in the United States and Canada. J Crit Care. 2014; 29:955–960
1. MacLaren R, Dionne JC, Granholm A, et al.: Society of Critical Care Medicine and American Society of Health-System Pharmacists guideline for the prevention of stress-related gastrointestinal bleeding in critically ill adults. Crit Care Med. 2024; 52:e421–e430
1. Cook DJ, Pearl RG, Cook RJ, et al.: Incidence of clinically important bleeding in mechanically ventilated patients. J Intensive Care Med. 1991; 6:167–174
1. Cook DJ, Fuller HD, Guyatt GH, et al.: Risk factors for gastrointestinal bleeding in critically ill patients. N Engl J Med. 1994; 330:377–381

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Executive Summary-Society of Critical Care Medicine Guideline and American Society of Health-System Pharmacists for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults

Affiliations

Executive Summary-Society of Critical Care Medicine Guideline and American Society of Health-System Pharmacists for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults

Authors

Affiliations

Erratum in

Conflict of interest statement

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical