Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma

doi:10.1007/s13402-024-00970-6

Review

. 2024 Oct;47(5):1561-1578.

doi: 10.1007/s13402-024-00970-6. Epub 2024 Jul 15.

Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma

Xiaoying Li^#¹, Wanting Hou^#¹, Chaoxin Xiao², Heqi Yang¹, Chengjian Zhao², Dan Cao³

Affiliations

¹ Department of Abdominal Oncology, Division of Abdominal Tumor Multimodality Treatment, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610017, People's Republic of China.
² State Key Laboratory of Biotherapy and Cancer Center, West China HospitaL, Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, Sichuan, 610017, People's Republic of China.
³ Department of Abdominal Oncology, Division of Abdominal Tumor Multimodality Treatment, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610017, People's Republic of China. caodan@scu.edu.cn.

^# Contributed equally.

PMID: 39008192
DOI: 10.1007/s13402-024-00970-6

Review

Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma

Xiaoying Li et al. Cell Oncol (Dordr). 2024 Oct.

. 2024 Oct;47(5):1561-1578.

doi: 10.1007/s13402-024-00970-6. Epub 2024 Jul 15.

Authors

Xiaoying Li^#¹, Wanting Hou^#¹, Chaoxin Xiao², Heqi Yang¹, Chengjian Zhao², Dan Cao³

Affiliations

¹ Department of Abdominal Oncology, Division of Abdominal Tumor Multimodality Treatment, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610017, People's Republic of China.
² State Key Laboratory of Biotherapy and Cancer Center, West China HospitaL, Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, Sichuan, 610017, People's Republic of China.
³ Department of Abdominal Oncology, Division of Abdominal Tumor Multimodality Treatment, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610017, People's Republic of China. caodan@scu.edu.cn.

^# Contributed equally.

PMID: 39008192
DOI: 10.1007/s13402-024-00970-6

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance to various treatment modalities. The genetic heterogeneity of PDAC, coupled with the presence of a desmoplastic stroma within the tumor microenvironment (TME), contributes to an unfavorable prognosis. The mechanisms and consequences of interactions among different cell types, along with spatial variations influencing cellular function, potentially play a role in the pathogenesis of PDAC. Understanding the diverse compositions of the TME and elucidating the functions of microscopic neighborhoods may contribute to understanding the immune microenvironment status in pancreatic cancer. As we delve into the spatial biology of the microscopic neighborhoods within the TME, aiding in deciphering the factors that orchestrate this intricate ecosystem. This overview delineates the fundamental constituents and the structural arrangement of the PDAC microenvironment, highlighting their impact on cancer cell biology.

Keywords: Pancreatic ductal adenocarcinoma; Spatial perspective; Tumor microenvironment.

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References

1. P. Rawla, T. Sunkara, V. Gaduputi, Epidemiology of pancreatic Cancer: global trends, etiology and risk factors. World J. Oncol. 10(1), 10–27 (2019). https://doi.org/10.14740/wjon1166 - DOI - PubMed - PMC
1. H. Sung, J. Ferlay, R.L. Siegel et al., Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021). https://doi.org/10.3322/caac.21660 - DOI - PubMed
1. J.D. Mizrahi, R. Surana, J.W. Valle et al., Pancreatic cancer. Lancet. 395(10242), 2008–2020 (2020). https://doi.org/10.1016/s0140-6736(20)30974-0 - DOI - PubMed
1. N.A. Ullman, P.R. Burchard, R.F. Dunne et al., Immunologic strategies in pancreatic Cancer: making Cold tumors Hot. J. Clin. Oncol. 40(24), 2789–2805 (2022). https://doi.org/10.1200/jco.21.02616 - DOI - PubMed - PMC
1. A.A. Connor, S. Gallinger, Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data. Nat Rev Cancer. 22(3): 131– 42 (2022). https://doi.org/10.1038/s41568-021-00418-1

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[1] P. Rawla, T. Sunkara, V. Gaduputi, Epidemiology of pancreatic Cancer: global trends, etiology and risk factors. World J. Oncol. 10(1), 10–27 (2019). https://doi.org/10.14740/wjon1166 - DOI - PubMed - PMC

[2] P. Rawla, T. Sunkara, V. Gaduputi, Epidemiology of pancreatic Cancer: global trends, etiology and risk factors. World J. Oncol. 10(1), 10–27 (2019). https://doi.org/10.14740/wjon1166 - DOI - PubMed - PMC

[3] H. Sung, J. Ferlay, R.L. Siegel et al., Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021). https://doi.org/10.3322/caac.21660 - DOI - PubMed

[4] H. Sung, J. Ferlay, R.L. Siegel et al., Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021). https://doi.org/10.3322/caac.21660 - DOI - PubMed

[5] J.D. Mizrahi, R. Surana, J.W. Valle et al., Pancreatic cancer. Lancet. 395(10242), 2008–2020 (2020). https://doi.org/10.1016/s0140-6736(20)30974-0 - DOI - PubMed

[6] J.D. Mizrahi, R. Surana, J.W. Valle et al., Pancreatic cancer. Lancet. 395(10242), 2008–2020 (2020). https://doi.org/10.1016/s0140-6736(20)30974-0 - DOI - PubMed

[7] N.A. Ullman, P.R. Burchard, R.F. Dunne et al., Immunologic strategies in pancreatic Cancer: making Cold tumors Hot. J. Clin. Oncol. 40(24), 2789–2805 (2022). https://doi.org/10.1200/jco.21.02616 - DOI - PubMed - PMC

[8] N.A. Ullman, P.R. Burchard, R.F. Dunne et al., Immunologic strategies in pancreatic Cancer: making Cold tumors Hot. J. Clin. Oncol. 40(24), 2789–2805 (2022). https://doi.org/10.1200/jco.21.02616 - DOI - PubMed - PMC

[9] A.A. Connor, S. Gallinger, Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data. Nat Rev Cancer. 22(3): 131– 42 (2022). https://doi.org/10.1038/s41568-021-00418-1

[10] A.A. Connor, S. Gallinger, Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data. Nat Rev Cancer. 22(3): 131– 42 (2022). https://doi.org/10.1038/s41568-021-00418-1

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Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma

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Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma

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