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Review
. 2024 Oct;47(5):1561-1578.
doi: 10.1007/s13402-024-00970-6. Epub 2024 Jul 15.

Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma

Xiaoying Li #  1 , Wanting Hou #  1 , Chaoxin Xiao  2 , Heqi Yang  1 , Chengjian Zhao  2 , Dan Cao  3
Affiliations
Review

Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma

Xiaoying Li et al. Cell Oncol (Dordr). 2024 Oct.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance to various treatment modalities. The genetic heterogeneity of PDAC, coupled with the presence of a desmoplastic stroma within the tumor microenvironment (TME), contributes to an unfavorable prognosis. The mechanisms and consequences of interactions among different cell types, along with spatial variations influencing cellular function, potentially play a role in the pathogenesis of PDAC. Understanding the diverse compositions of the TME and elucidating the functions of microscopic neighborhoods may contribute to understanding the immune microenvironment status in pancreatic cancer. As we delve into the spatial biology of the microscopic neighborhoods within the TME, aiding in deciphering the factors that orchestrate this intricate ecosystem. This overview delineates the fundamental constituents and the structural arrangement of the PDAC microenvironment, highlighting their impact on cancer cell biology.

Keywords: Pancreatic ductal adenocarcinoma; Spatial perspective; Tumor microenvironment.

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