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Case Reports
. 2024 Sep 1;47(9):e65-e66.
doi: 10.2337/dc24-0730.

Use of a Dual GIP/GLP-1 Receptor Agonist in HNF1A-MODY and HNF4A-MODY

Affiliations
Case Reports

Use of a Dual GIP/GLP-1 Receptor Agonist in HNF1A-MODY and HNF4A-MODY

David T Broome et al. Diabetes Care. .
No abstract available

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Conflict of interest statement

Duality of Interest. D.T.B. is a research investigator for Fractyl Health Laboratories and Rhythm Pharmaceuticals. M.F.d.F. is an advisory board member for PTC Pharmaceuticals and was a scientific presenter in a symposium funded by Amryt Pharmaceuticals. E.A.O. has received grant support from Aegerion Pharmaceuticals (manufacturer of metreleptin), Akcea Therapeutics, Ionis Pharmaceuticals, Gemphire Therapeutics, Novo Nordisk, Rhythm Pharmaceuticals, Fractyl Health Laboratories, and GI Dynamics. E.A.O. has served as an advisor and/or a consultant to Aegerion Pharmaceuticals, Akcea Therapeutics, Ionis Pharmaceuticals, and Regeneron. E.A.O. has royalty rights from the use of metreleptin in lipodystrophy. W.H.H. is on data safety and monitoring boards for Merck Sharp & Dohme and Rivus Pharmaceuticals. No other potential conflicts of interest relevant to this article were reported.

References

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    1. Shields BM, Hicks S, Shepherd MH, et al. . Maturity-onset diabetes of the young (MODY): how many cases are we missing? Diabetalogia 2010;53:2504–2508 - PubMed
    1. Østoft SH, Bagger JI, Hansen T, et al. . Glucose-lowering effects and low risk of hypoglycemia in patients with maturity-onset diabetes of the young when treated with a GLP-1 receptor agonist: a double-blind, randomized, crossover trial. Diabetes Care 2014;37:1797–1805 - PubMed
    1. Christensen AS, Hædersdal S, Storgaard H, et al. . GIP and GLP-1 potentiate sulfonylurea-induced insulin secretion in hepatocyte nuclear factor 1α mutation carriers. Diabetes 2020;69:1989–2002 - PMC - PubMed
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