Efficacy and safety of switching from Eculizumab to Ravulizumab for the maintenance of aHUS remission after kidney transplant: a preliminary experience
- PMID: 39009796
- PMCID: PMC11649733
- DOI: 10.1007/s40620-024-02005-7
Efficacy and safety of switching from Eculizumab to Ravulizumab for the maintenance of aHUS remission after kidney transplant: a preliminary experience
Conflict of interest statement
Declarations. Conflict of interest: The authors have nothing to disclose. Ethical approval: The study was conducted in accordance with the standards as laid down in the in the 1964 Declaration of Helsinki and its later amendments, and was approved by IRCCS AOU Bologna Ethics Committee (cod. 586/2023/Oss/AOUBo). Ethical approval was waived by the local Ethics Committee of University of Bologna, in view of the retrospective nature of the study and all the procedures being performed were part of the routine care. Informed consent: Patients gave informed consent for publication of their data.
References
-
- Rondeau E, Scully M, Ariceta G, Barbour T, Cataland S, Heyne N, Miyakawa Y, Ortiz S, Swenson E, Vallee M, Yoon SS, Kavanagh D, Haller H (2021) The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment. Kidney Int 97(6):1287–1296 10.1016/j.kint.2020.01.035(Epub 2020 Mar 6. Erratum in: Kidney Int 98(6):1621. Erratum in: Kidney Int 99(5):1244 PMID: 32299680) - PubMed
-
- Maritati F, Corradetti V, Bini C, Provenzano M, Cuna V, Busutti M, Tondolo F, Zappulo F, Vischini G, Iacovella F, Abenavoli C, Borelli G, Demetri M, Fabbrizio B, Radi G, Ravaioli M, Mele C, La Manna G, Comai G (2024) Eculizumab first in the management of posttransplant thrombotic microangiopathy. Kidney Int Rep 9:982–993 - PMC - PubMed
-
- Barbour T, Scully M, Ariceta G, Cataland S, Garlo K, Heyne N, Luque Y, Menne J, Miyakawa Y, Yoon SS, Kavanagh D, 311 Study Group Members (2021) Long-term efficacy and safety of the long-acting complement C5 inhibitor ravulizumab for the treatment of atypical hemolytic uremic syndrome in adults. Kidney Int Rep 6(6):1603–1613. 10.1016/j.ekir.2021.03.884 - PMC - PubMed
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
