Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 15;14(1):16312.
doi: 10.1038/s41598-024-67580-y.

Association between the serum uric acid/serum creatinine ratio and cognitive function in older adults: NHANES in the United States

Gang Chen #  1 , Ling Tong #  2 , Qing Ye  3
Affiliations

Association between the serum uric acid/serum creatinine ratio and cognitive function in older adults: NHANES in the United States

Gang Chen et al. Sci Rep. .

Abstract

Cognitive impairment can potentially become a significant health concern in older adults. However, early effective diagnostic methods are still lacking. Therefore, we utilized the NHANES database in the US to investigate the relationship between serum uric acid to serum creatinine (SUA/SCR) ratio and cognitive impairment. In our study, a total of 3874 participants were included (2001-2002, 2011-2014). Weighted t tests or chi-square tests were utilized to analyze the basic characteristics of the population. Weighted logistic regression analysis, smooth-fit curves, threshold effects, and subgroup analysis were conducted to investigate the correlation between the SUA/SCR and cognitive impairment. In this study, the SUA/SCR was significantly lower in individuals with cognitive impairment. The logistic regression model, after adjusting for all covariates, revealed that the Q2-Q4 were 0.65 (95% CI 0.49, 0.86), 0.60 (95% CI 0.40, 0.90), 0.55 (95% CI 0.39, 0.77) respectively. This indicates that participants in the Q4 had a 45% reduced risk of cognitive impairment. Smooth-fit curves and threshold effect analysis revealed a nonlinear relationship between SUA/SCR and cognitive impairment, with a turning point at 4.13. Subgroup analysis showed no statistically significant differences in the relationship between SUA/SCR and cognitive impairment among different subgroups (P > 0.05). Our findings indicate a negative correlation between the SUA/SCR and the risk of cognitive impairment in the population of adults aged 60 and above in the US. This suggests that the SUA/SCR holds promise as a potential indicator for cognitive impairment.

Keywords: Cognitive impairment; SUA/SCR ratio; Serum creatinine; Serum uric acid.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Screening flowchart.
Figure 2
Figure 2
The association between SUA/SCR and cognitive impairment. The red line represents the smoothed curve fit between the variables, while the blue line represents the fitted 95% confidence interval.
Figure 3
Figure 3
Subgroup analysis of the association between SUA/SCR and cognitive impairment.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Jessen F, Amariglio RE, Buckley RF, et al. The characterisation of subjective cognitive decline. Lancet Neurol. 2020;19(3):271–278. doi: 10.1016/S1474-4422(19)30368-0. - DOI - PMC - PubMed
    1. Alzheimer's disease facts and figures Alzheimers Dement. 2021;17(3):327–406. doi: 10.1002/alz.12328. - DOI - PubMed
    1. Wei L, Zhang Y, Wang J, et al. Parietal-hippocampal rTMS improves cognitive function in Alzheimer's disease and increases dynamic functional connectivity of default mode network. Psychiatry Res. 2022;315:114721. doi: 10.1016/j.psychres.2022.114721. - DOI - PubMed
    1. Wang D, Liu L, Li K, et al. Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction. J. Nat. Med. 2023;77(4):867–879. doi: 10.1007/s11418-023-01729-3. - DOI - PubMed
    1. Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: A hypothesis. Proc. Natl. Acad. Sci. USA. 1981;78(11):6858–6862. doi: 10.1073/pnas.78.11.6858. - DOI - PMC - PubMed

LinkOut - more resources