Altered thalamus functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study

Abstract

Objective: Acute unilateral vestibulopathy (AUVP) is the second leading cause of peripheral vestibular vertigo. Full recovery of AUVP is related to sufficient central vestibular compensation. It has been confirmed that the vestibular nucleus and vestibular cortex are involved in the process of vestibular compensatory in AUVP patients. However, few studies have focused on the functional compensation of thalamus in patients with AUVP. This study aimed to explore the alterations of resting-state functional connectivity (FC) focused on thalamus using functional magnetic resonance imaging (fMRI) in AUVP patients.

Methods: Data of 3D-T1 and resting-state fMRI were collected from 40 AUVP patients and 35 healthy controls (HC). Seeds-based (bilateral thalamus) FC was analyzed to investigate the changes in FC between the two groups. Furthermore, we evaluated the associations between altered thalamus FC and clinical features in AUVP patients using Pearson's partial correlation.

Results: Compared with HC, AUVP patients showed decreased FC between bilateral thalamus and left insula. We also observed decreased FC between right thalamus and left supramarginal gyrus. Additionally, we found increased FC between left thalamus and right postcentral gyrus (PCG), as well as increased FC between right thalamus and regions of bilateral PCG, right middle frontal gyrus and right middle occipital gyrus in AUVP patients. Furthermore, the FC between left thalamus and left insula was negatively correlated with values of canal paresis in patients with AUVP (p = 0.010, r = -0.434).

Conclusion: Our results provided first evidence for the decreased thalamo-vestibular cortex pathway, as well as increased thalamo-somatosensory and thalamo-visual cortex pathway in AUVP patients. These findings help us better understand the underlying mechanisms of central dynamic compensatory following an acute unilateral peripheral vestibular damage.

Keywords: acute unilateral vestibulopathy; functional connectivity; resting-state fMRI; thalamus; vestibular compensation; vestibular neuritis.

FIGURE 1

Differences in functional connectivity (FC) between patients with AUVP and healthy controls when the left thalamus was chosen as a seed. Blue and cyan regions suggest decreased FC, while red and yellow areas indicate increased FC [voxel-level threshold (p < 0.001) and cluster-level threshold (two-tailed, p < 0.05, FDR correction)]. AUVP, acute unilateral vestibulopathy; FDR, false discovery rate; L, left; R, right.

FIGURE 2

Differences in functional connectivity (FC) between patients with AUVP and healthy controls when the right thalamus was chosen as a seed. Blue and cyan regions suggest decreased FC, while red and yellow areas indicate increased FC [voxel-level threshold (p < 0.001) and cluster-level threshold (two-tailed, p < 0.05, FDR correction)]. AUVP, acute unilateral vestibulopathy; FDR, false discovery rate; L, left; R, right.

FIGURE 3

Functional connectivity between the left insula and left thalamus was negatively correlated with the value of canal paresis (CP) in patients with acute unilateral vestibulopathy (p = 0.010, r = –0.434).