Predicting Adverse Events to Thiopurines in IBD: Are We a Step Closer?
- PMID: 39011862
- DOI: 10.1093/ibd/izae125
Predicting Adverse Events to Thiopurines in IBD: Are We a Step Closer?
Abstract
Thiopurines remain an important option in the treatment of IBD. However, the unpredictable and sometimes serious side effects and intolerance remain a major challenge. Pretreatment of extended genetic panel analysis, identification of novel variants, and monitoring of intermediate metabolites will help improve the overall outcome and reduce the toxicity.
Keywords: GenePy score; nudix hydroxylase (NUDT 15); thiopurine methyltransferase (TPMT).
© The Author(s) 2024. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
Comment in
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Reply: Predicting Adverse Events to Thiopurines in IBD: Are We a Step Closer?Inflamm Bowel Dis. 2024 Oct 3;30(10):1928-1930. doi: 10.1093/ibd/izae130. Inflamm Bowel Dis. 2024. PMID: 39011772 No abstract available.
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DNA-Thioguanine (DNA-TG) Is a Promising Novel Method to Predict Adverse Events to Thiopurine in Inflammatory Bowel Disease.Inflamm Bowel Dis. 2025 Feb 10;31(2):612-613. doi: 10.1093/ibd/izae234. Inflamm Bowel Dis. 2025. PMID: 39446572 No abstract available.
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Editorial Response to the Letter Relating to our Article "Predicting Adverse Events to Thiopurines in IBD: Are We a Step Closer?".Inflamm Bowel Dis. 2025 Feb 10;31(2):614-615. doi: 10.1093/ibd/izae242. Inflamm Bowel Dis. 2025. PMID: 39447023 No abstract available.
Comment on
-
Reply: Predicting Adverse Events to Thiopurines in IBD: Are We a Step Closer?Inflamm Bowel Dis. 2024 Oct 3;30(10):1928-1930. doi: 10.1093/ibd/izae130. Inflamm Bowel Dis. 2024. PMID: 39011772 No abstract available.
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Pharmacogenomic Assessment of Genes Implicated in Thiopurine Metabolism and Toxicity in a UK Cohort of Pediatric Patients With Inflammatory Bowel Disease.Inflamm Bowel Dis. 2025 Feb 6;31(2):362-375. doi: 10.1093/ibd/izae126. Inflamm Bowel Dis. 2025. PMID: 39011784
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DNA-Thioguanine (DNA-TG) Is a Promising Novel Method to Predict Adverse Events to Thiopurine in Inflammatory Bowel Disease.Inflamm Bowel Dis. 2025 Feb 10;31(2):612-613. doi: 10.1093/ibd/izae234. Inflamm Bowel Dis. 2025. PMID: 39446572 No abstract available.
-
Editorial Response to the Letter Relating to our Article "Predicting Adverse Events to Thiopurines in IBD: Are We a Step Closer?".Inflamm Bowel Dis. 2025 Feb 10;31(2):614-615. doi: 10.1093/ibd/izae242. Inflamm Bowel Dis. 2025. PMID: 39447023 No abstract available.
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