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Editorial
. 2024 Nov 1;210(9):1075-1077.
doi: 10.1164/rccm.202406-1109ED.

Imaging the Intersection of Parenchymal Abnormalities and Pulmonary Vascular Pathways

Rebecca R Vanderpool  1
Affiliations
Editorial

Imaging the Intersection of Parenchymal Abnormalities and Pulmonary Vascular Pathways

Rebecca R Vanderpool. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
(A) Depiction of the pulmonary vasculature and corresponding airways. The preacinar arteries are more intermediate-sized arteries (aBV5–20 mm2) that are smaller than the main pulmonary artery but larger than the more distal vasculature (14). The CT/radiographic features are used to quantify the percentage of the parenchyma that is associated with QIA and percentage emphysema (6). (B) Highlighting the progressive impact of the pulmonary vascular dysfunction on the mediation of progression of the casual mediation results of the metrics of pulmonary vascular dysfunction. The metrics that measure more proximal features, including the RV/LV ratio and the PA/Ao ratio, were suppressive and partial mediators of the clinical outcome of the 6MWD, respectively. The main mediator was the preacinar arteries that mediated 79.6% of the outcome. 6MWD = 6-minute-walk distance; CT = computed tomography; PA/Ao ratio = pulmonary to aorta ratio; QIA = quantitative interstitial abnormalities; RV/LV ratio = right to left ventricle ratio.
See this image and copyright information in PMC

Comment on

  • Preacinar Arterial Dilation Mediates Outcomes of Quantitative Interstitial Abnormalities in the COPDGene Study.
    Harder EM, Nardelli P, Pistenmaa CL, Ash SY, Balasubramanian A, Bowler RP, Iturrioz Campo M, Diaz AA, Hassoun PM, Leopold JA, Martinez FJ, Nathan SD, Noth I, Podolanczuk AJ, Saggar R, San José Estépar R, Shlobin OA, Wang W, Waxman AB, Putman RK, Washko GR, Choi B, San José Estépar R, Rahaghi FN. Harder EM, et al. Am J Respir Crit Care Med. 2024 Nov 1;210(9):1132-1142. doi: 10.1164/rccm.202312-2342OC. Am J Respir Crit Care Med. 2024. PMID: 38820122 Free PMC article.

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