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Comment
. 2024 Jul 16;15(1):5948.
doi: 10.1038/s41467-024-49586-2.

Autotrophic yeast

Jens Nielsen  1
Affiliations
Comment

Autotrophic yeast

Jens Nielsen. Nat Commun. .

Abstract

Yeast is a widely used cell factory for the conversion of sugar into fuels, chemicals and pharmaceuticals. Establishing yeast as being autotrophic can enable it to grow solely on CO2 and light, and hereby yeast can be used as a wider platform for transition to a sustainable society.

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1. Establishment of yeast as an autotrophic organism that can convert CO2 and light into chemicals.
A By engulfing a cyanobacterium into yeast there was established a synthetic chloroplast that can convert CO2 and light into glucose. The formed glucose can be used by the cells to make more yeast cells, i.e. biomass. Part of the glucose can also be recruited for biosynthesis of valuable chemicals, e.g. terpenes. B The yeast/cyanobacterium chimera can be used more widely for conversion of CO2 and light into a wide range of products, i.e. fuels, chemicals, foods, materials and pharmaceuticals.
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References

    1. Gao, Y.-L. et al. Evolutionary engineering of Saccharomyces cerevisiae creating a synthetic methylotroph via self-reprogramming. Nat. Commun. (2024).
    1. Scalcinati G, et al. Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae. Mic. Cell Fac. 2012;11:117. doi: 10.1186/1475-2859-11-117. - DOI - PMC - PubMed
    1. Ro D-K, et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature. 2017;440:940–943. doi: 10.1038/nature04640. - DOI - PubMed
    1. Dusseaux S, et al. Transforming yeast peroxisomes into microfactories for the efficient production of high-value isoprenoids. Proc. Nat. Acad. Sci. USA. 2020;117:31789–31799. doi: 10.1073/pnas.2013968117. - DOI - PMC - PubMed
    1. Nielsen J. Yeast systems biology: Model organism and cell factory. Biotechnol. J. 2019;14:1800421. doi: 10.1002/biot.201800421. - DOI - PubMed

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