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Review
. 2024:1459:53-77.
doi: 10.1007/978-3-031-62731-6_3.

The Role of the Transcriptional Coactivator BOB.1/OBF.1 in Adaptive Immunity

Annika C Betzler  1   2 , Cornelia Brunner  3   4
Affiliations
Review

The Role of the Transcriptional Coactivator BOB.1/OBF.1 in Adaptive Immunity

Annika C Betzler et al. Adv Exp Med Biol. 2024.

Abstract

BOB.1/OBF.1 is a transcriptional coactivator involved in octamer-dependent transcription. Thereby, BOB.1/OBF.1 is involved in the transcriptional regulation of genes important for lymphocyte physiology. BOB.1/OBF.1-deficient mice reveal multiple B- and T-cell developmental defects. The most prominent defect of these mice is the complete absence of germinal centers (GCs) resulting in severely impaired T-cell-dependent immune responses. In humans, BOB.1/OBF.1 is associated with several autoimmune and inflammatory diseases but also linked to liquid and solid tumors. Although its role for B-cell development is relatively well understood, its exact role for the GC reaction and T-cell biology has long been unclear. Here, the contribution of BOB.1/OBF.1 for B-cell maturation is summarized, and recent findings regarding its function in GC B- as well as in various T-cell populations are discussed. Finally, a detailed perspective on how BOB.1/OBF.1 contributes to different pathologies is provided.

Keywords: Autoimmunity; B lymphocytes; BOB.1/OBF.1; Chronic inflammation; Germinal center; Lymphoma; Solid tumors; T lymphocytes; Transcriptional regulation.

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