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. 2024 Nov;50(1):330-331.
doi: 10.1038/s41386-024-01928-w.

Pump the brakes: identifying neurobiological targets to enhance inhibitory control in drug addiction

Ahmet O Ceceli  1 , Rita Z Goldstein  2
Affiliations

Pump the brakes: identifying neurobiological targets to enhance inhibitory control in drug addiction

Ahmet O Ceceli et al. Neuropsychopharmacology. 2024 Nov.

Erratum in

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Inhibitory control brain activity increases with inpatient treatment in individuals with heroin use disorder (iHUD).
Right anterior prefrontal cortex (aPFC) (A) and right dorsolateral PFC (dlPFC) (B) activity during successful versus failed stops on the stop-signal task showed significant increases from baseline (session 1) to a 15-week follow-up (session 2) in the iHUD group compared to healthy controls (HC). Brain activity changes in HC did not meet significance. Figure adapted from Ceceli et al. [5], Nature Mental Health [6] with permission.
See this image and copyright information in PMC

References

    1. Garavan H, Potter AS, Brennan KL, Foxe JJ. Neural bases of addiction-related impairments in response inhibition. The Wiley Handbook on the Cognitive Neuroscience of Addiction. John Wiley & Sons, Ltd; 2015. p. 29–54.
    1. Menon V, D’Esposito M. The role of PFC networks in cognitive control and executive function. Neuropsychopharmacol. 2022;47:90–103. - DOI - PMC - PubMed
    1. Ceceli AO, Parvaz MA, King S, Schafer M, Malaker P, Sharma A, et al. Altered prefrontal signaling during inhibitory control in a salient drug context in cocaine use disorder. Cereb Cortex. 2022;33:597–611. - PMC - PubMed
    1. Ceceli AO, King S, McClain N, Alia-Klein N, Goldstein RZ. The neural signature of impaired inhibitory control in individuals with heroin use disorder. J Neurosci. 2022;43:173–82. - PMC - PubMed
    1. Ceceli AO, Huang Y, Gaudreault P-O, McClain NE, King SG, Kronberg G, et al. Recovery of anterior prefrontal cortex inhibitory control after 15 weeks of inpatient treatment in heroin use disorder. Nat Mental Health. 2024;2:694–702.

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