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. 2024 Nov;50(1):312-313.
doi: 10.1038/s41386-024-01921-3.

Rewiring the brain: Inflammation's impact on glutamate and neural networks in depression

Ebrahim Haroon  1 , Andrew H Miller  2
Affiliations

Rewiring the brain: Inflammation's impact on glutamate and neural networks in depression

Ebrahim Haroon et al. Neuropsychopharmacology. 2024 Nov.

Erratum in

No abstract available

PubMed Disclaimer

Conflict of interest statement

EH denies the presence of competing interests or conflicts. AHM is a paid consultant for Cerevel Therapeutics, Sirtsei Pharmaceuticals Inc., and Freedom Biosciences.

References

    1. Haroon E, Miller AH, Sanacora G. Inflammation, Glutamate, and Glia: A trio of trouble in mood disorders. Neuropsychopharmacology. 2017;42:193–215. - PMC - PubMed
    1. Haroon E, Woolwine BJ, Chen X, Pace TW, Parekh S, Spivey JR, et al. IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy. Neuropsychopharmacology. 2014;39:1777–85. - PMC - PubMed
    1. Haroon E, Felger JC, Woolwine BJ, Chen X, Parekh S, Spivey JR, et al. Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings. Brain Behav Immun. 2015;46:17–22. - PMC - PubMed
    1. Haroon E, Fleischer CC, Felger JC, Chen X, Woolwine BJ, Patel T, et al. Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression. Mol Psychiatry. 2016;21:1351–7. - PMC - PubMed
    1. Chen X, Beltran DJ, Tsygankova VD, Woolwine BJ, Patel T, Baer W, et al. Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression. Transl Psychiatry. 2021;11:456. - PMC - PubMed

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