Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1985 Sep;7(3):178-82.

Quantitative description of chromatin structure during neoplasia by the method of image processing

  • PMID: 3902049
Comparative Study

Quantitative description of chromatin structure during neoplasia by the method of image processing

D Komitowski et al. Anal Quant Cytol Histol. 1985 Sep.

Abstract

Nuclear chromatin is visualized by light microscopy as a mosaic of interchanging regions of low and high optical density (O.D.). The regions of high O.D. are well-defined as chromatin particles; features characterizing these particles enable the description of chromatin structure and the recognition of its changes during neoplasia. This paper presents a method of feature extraction by means of digital image analysis, based on a localization algorithm with locally adaptive thresholding. Although the chromatin particles varied greatly in their O.D., the algorithm enabled the identification of significant numbers of particles, which is essential in characterizing the complex architecture of chromatin. The results obtained by studying neoplastic nuclei and nuclei from control tissue suggest that the appearance of an additional class of chromatin particles, defined by their localization and optical density, is typical of chromatin changes during neoplasia.

PubMed Disclaimer

Publication types

LinkOut - more resources