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Comparative Study
. 2024 Oct;91(4):278-284.
doi: 10.1111/cod.14632. Epub 2024 Jul 17.

Epidemiology of patch tested patients with permanent tattoos-A comparative analysis of 9693 IVDK patients (2020-2022)

Steffen Schubert  1 , Eva Oppel  2 , Andrea Bauer  3 , Claudia Schröder-Kraft  4 , Harald Löffler  5 , Kerstin Strom  6 , Margitta Worm  7 , Richard Brans  8   9 , Nicola Wagner  10 , Yenny Angela  11 , Johannes Geier  1 ; IVDK
Collaborators, Affiliations
Comparative Study

Epidemiology of patch tested patients with permanent tattoos-A comparative analysis of 9693 IVDK patients (2020-2022)

Steffen Schubert et al. Contact Dermatitis. 2024 Oct.

Abstract

Background: Permanent tattooing is the invasive introduction of tattoo ink (pigments) into the dermis. The ink and aftercare cosmetics applied on pre-damaged skin may contain skin sensitisers.

Objectives: To identify patient characteristics and the pattern of sensitisation in tattooed patients patch tested within the Information Network of Departments of Dermatology (IVDK).

Patients and methods: Comparative analysis of patient characteristics and reaction frequencies to baseline series allergens in 1648 consecutive patients with and 8045 consecutive patients without permanent tattoos. Non-overlapping 95%-confidence intervals were considered as significant.

Results: Having permanent tattoos was related with female sex, age <40 years, tobacco smoking, atopic dermatitis, (occupational) hand dermatitis and being employed in particular occupational groups (e.g., healthcare workers, mechanics, hairdressers). Sensitisation to nickel was increased in tattooed patients and associated with female sex (OR 4.23 [95%-CI, 3.48-5.18]), age ≥40 years (OR 1.26 [95%-CI, 1.08-1.49]), tobacco smoking (OR 1.19 [95%-CI, 1.01-1.40]) and having permanent tattoos (OR 1.27 [95%-CI, 1.05-1.53]).

Conclusions: The association between nickel sensitisation and permanent tattoos is probably confounded by past reactions to pierced costume jewellery. Socio-economic factors most probably contribute to the connection between tattoos, tobacco smoking, occupational or hand dermatitis, and being employed in particular occupational groups.

Keywords: allergic contact dermatitis; nickel; patch test; permanent make‐up; tattoo; tattoo aftercare cosmetics.

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References

REFERENCES

    1. Schubert S, Kluger N, Schreiver I. Hypersensitivity to permanent tattoos: literature summary and comprehensive review of patch tested tattoo patients 1997‐2022. Contact Derm. 2023;88(5):331‐350.
    1. Martin SF, Esser PR, Weber FC, et al. Mechanisms of chemical‐induced innate immunity in allergic contact dermatitis. Allergy. 2011;66(9):1152‐1163.
    1. Liou YL, Liszewski W, Schlarbaum JP, Warshaw EM. Characterization of tattoo aftercare products: allergenic ingredients and marketing claims. Dermatitis. 2021;32(5):301‐307.
    1. van der Bent SAS, Rauwerdink D, Oyen EMM, Maijer KI, Rustemeyer T, Wolkerstorfer A. Complications of tattoos and permanent makeup: overview and analysis of 308 cases. J Cosmet Dermatol. 2021;20(11):3630‐3641.
    1. Serup J, Hutton CK. Patch test study of 90 patients with tattoo reactions: negative outcome of allergy patch test to baseline batteries and culprit inks suggests allergen(s) are generated in the skin through haptenization. Contact Derm. 2014;71(5):255‐263.

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