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. 2024 May 30:18:1706.
doi: 10.3332/ecancer.2024.1706. eCollection 2024.

Survival trends in gastric cancer in Brazil: real-life data from a large cancer center

Angelo Borsarelli Carvalho Brito  1 , Tiago Cordeiro Felismino  1 , Diego Rodrigues Mendonca E Silva  2 , Maria Paula Curado  2 , Lais Corsino Durant  3 , Rodrigo Gomes Taboada  1 , Adriane Graicer Pelosof  4 , Alessandro Landskron Diniz  3 , Felipe Jose Fernandez Coimbra  3
Affiliations

Survival trends in gastric cancer in Brazil: real-life data from a large cancer center

Angelo Borsarelli Carvalho Brito et al. Ecancermedicalscience. .

Abstract

Background: Gastric cancer (GC) is the fourth leading cause of cancer deaths globally. There is a paucity of real-life data on GC in Brazil. Our study aimed to evaluate survival trends in gastric adenocarcinoma (GA) in a large cancer center in Brazil during 2000-2017.

Methods: Based on our Hospital Cancer Registry Database, all individuals diagnosed with GA between 2000 and 2017, and treated at A.C. Camargo Cancer Center, were retrospectively included. The primary objectives were to describe the patient demographics, clinicopathological characteristics, treatment modalities and survival trends during four separate periods of diagnosis (2000-2004; 2005-2009; 2010-2014 and 2015-2017). χ2 test was performed between two specified periods (2000-2004 and 2015-2017) to compare categorical variables. Overall survival (OS) curves were stratified by four separate periods and compared with log-rank tests.

Results: This analysis included 1,406 individuals. Across all periods, most patients were men aged 50-69 and presented with Lauren's intestinal subtype. The frequency of stage IV disease significantly decreased between 2000-2004 and 2015-2017 (43.6% to 32.8%, p < 0.001). In contrast, we observed a rise in stage II (9.4% to 24.8%, p < 0.001) in the same comparison. We noticed an increased utilization of a combined approach involving chemotherapy and surgery (12% in 2000-2004 and 36.3% in 2015-2017, p < 0.001). The predicted 5-year OS of patients with GA in 2000-2004 was 27.8%, which increased to 53.9% in 2015-2017 (p < 0.001).

Conclusion: Our retrospective cohort showed an upward trend in survival rates during the period. We observed that 5-year OS almost doubled among men and women during 2000-2017.

Mini abstract: The present retrospective cohort showed an upward trend in survival rates during the period from 2000 to 2017, in which the OS almost doubled among men and women.

Keywords: epidemiology; gastric cancer; prognosis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.. 5-year OS for GA stratified by diagnosis period.
Figure 2.
Figure 2.. 5-year OS for GA stratified by sex and diagnosis period.
See this image and copyright information in PMC

References

    1. INSTITUTO NACIONAL DE CÂNCER JOSÉ ALENCAR GOMES DA SILVA. Estimativa 2023: incidência do Câncer no Brasil. Rio de Janeiro: INCA Dehwgb;
    1. Morgan E, Arnold M, Camargo MC, et al. The current and future incidence and mortality of gastric cancer in 185 countries, 2020–40: a population-based modelling study. EClinicalMedicine. 2022;47:101404. doi: 10.1016/j.eclinm.2022.101404. (In eng) - DOI - PMC - PubMed
    1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660. (In eng) - DOI - PubMed
    1. Bray F, Ferlay J, Laversanne M, et al. Cancer incidence in five continents: inclusion criteria, highlights from volume X and the global status of cancer registration. Int J Cancer. 2015;137(9):2060–2071. doi: 10.1002/ijc.29670. (In eng) - DOI - PubMed
    1. Bertuccio P, Chatenoud L, Levi F, et al. Recent patterns in gastric cancer: a global overview. Int J Cancer. 2009;125(3):666–673. doi: 10.1002/ijc.24290. (In eng) - DOI - PubMed

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