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. 2024 Jun 28;58(2):189-196.
doi: 10.14744/SEMB.2024.37043. eCollection 2024.

The Effects of Ketamine-Propofol and Remifentanil-Propofol Combinations on Integrated Pulmonary Index During Sedation in Gastrointestinal System Endoscopy

Zuhal Cavus  1 , Dondu Genc Moralar  1 , Ayfer Kaya Gok  1 , Ali Selman Gunaydin  1
Affiliations

The Effects of Ketamine-Propofol and Remifentanil-Propofol Combinations on Integrated Pulmonary Index During Sedation in Gastrointestinal System Endoscopy

Zuhal Cavus et al. Sisli Etfal Hastan Tip Bul. .

Abstract

Objectives: Different sedo-analgesia and monitoring methods are used during endoscopic procedures. And yet, there is no consensus on optimal sedating agents. In this study, the main aim is to compare ketamine-propofol and remifentanil propofol sedo-analgesia protocols by monitoring integrated pulmonary index (IPI).

Methods: The study population is divided into two groups: Group ketamine received 0.25 mg/kg ketamine and 0.75 mg/kg propofol at the beginning of anesthesia. 1 mcg/kg of remifentanil and 0.75 mg/kg propofol were administered to group remifentanil patients at the induction of anesthesia. Anesthesia maintenance was provided by titration of drug doses according to the Ramsey sedation scale. Measurements were taken at four different points in time: just before anesthesia was induced, five minutes after sedation was induced, ten minutes later, and five minutes after the treatment was finished.

Results: There was no significant difference in respiratory parameters such as respiratory rate, SPO2, and EtCO2 measured in the T1 time period between the groups. In the T2 time period, a significant difference was found between the groups in the integrated pulmonary index (IPI), sPO2, respiratory rate, and systolic pressure parameters were found to be significantly higher in group ketamine. T3 time period results were higher in these three parameters: IPI, sPO2, and respiration rate. In the T2, T3, T4 time periods, there was a difference between the groups in the respiration count parameter and it was found to be higher in group ketamine.

Conclusion: Although it causes slight prolongation in recovery, ketamine is a safe and effective drug that can be used during endoscopic procedures.

Keywords: Capnography; endoscopy; sedation.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1
Figure 1
A flow diagram of allocated patients.
Figure 2
Figure 2
Comparing IPI scores between groups in different time periods. Baseline: just before sedation was induced, T1: five minutes after sedation was induced, T2: ten minutes later, T3: five minutes after the procedure was finished.
Figure 3
Figure 3
Comparing RSS score and recovery period among groups.
See this image and copyright information in PMC

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