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. 2024 Jun 28;58(2):171-178.
doi: 10.14744/SEMB.2024.84453. eCollection 2024.

Relationship Between Platelet Parameters and Eosinophils with Disease Severity, CRP and Treatment in Stable COPD

Zeynep Mine Yalcinkaya Kara  1 , Sema Yagci  1 , Mufide Arzu Ozkarafakili  2 , Mustafa Ilteris Bardakci  2
Affiliations

Relationship Between Platelet Parameters and Eosinophils with Disease Severity, CRP and Treatment in Stable COPD

Zeynep Mine Yalcinkaya Kara et al. Sisli Etfal Hastan Tip Bul. .

Abstract

Objectives: Chronic obstructive pulmonary disease (COPD) is a complex inflammatory condition that primarily impairs respiration but can also affect hemostasis. This study aimed to determine differences in platelet-related parameters and eosinophil between COPD patients and healthy controls.

Methods: We included 149 patients with stable COPD and 30 healthy controls who were recruited from the outpatient department of Chest Diseases. Complete blood count, including platelet count (Plt), and C-reactive protein were measured. Other platelet-related parameters were determined, including mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (Pct), their ratios (MPV/Plt, MPV/Pct, PDW/Plt, PDW/Pct), and platelet to lymphocyte ratio (PLR).

Results: COPD patients and controls did not show significant differences in platelet parameters (Plt, Pct, PDW, MPV, PDW/Pct, MPV/Pct). PLR was significantly higher in the patient groups than in the control group (p=0.009). Correlation between platelet count and PLR (p=0.047; p=0.05) showed borderline significance. However, we found no correlation between the patients' CRP levels, Pct, PDW, PDW/Pct, MPV/Pct and MPV values. There were no significant differences in platelet parameters in patients using and not using long-acting muscarinic antagonists (LAMA). We did not find differences in eosinophil levels among COPD severity grades.

Conclusion: In our study, we found that PLR is elevated in COPD. PLR could be a useful and easily accessible parameter to evaluate ongoing inflammation in stable COPD. Large-scale studies are warranted to further investigate the role of platelet and eosinophil parameters in COPD.

Keywords: COPD; eosinophil; inflammation; platelet related parameters.

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Conflict of interest statement

None declared.

References

    1. Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med. 2017;195:557–82. - PubMed
    1. GBD 2015 Chronic Respiratory Disease Collaborators Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma 1990-2015: a systematic analysis for the global burden of disease study 2015. Lancet Respir Med. 2017;5:691–706. Erratum Lancet Respir Med 2017 5 e30. - PMC - PubMed
    1. Singh D, Agusti A, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019. Eur Respir J. 2019;53:1900164. doi: 10.1183/13993003.00164-2019. - DOI - PubMed
    1. Stokes KY, Granger DN. Platelets: a critical link between inflammation and microvascular dysfunction. J Physiol. 2012;590:1023–34. - PMC - PubMed
    1. Canat MM, Yarkutay Turkkan C, Erhan H, Yener Ozturk F, Altuntas Y. The role of serum inflammation-based scores in diagnosis and assessing remission in Cushing’s disease. Sisli Etfal Hastan Tip Bul. 2023;57:250–6. doi: 10.14744/SEMB.2023.14306. - DOI - PMC - PubMed

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