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Review
. 2024 Jul 3:15:1365639.
doi: 10.3389/fphar.2024.1365639. eCollection 2024.

Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis

Chen-Fei Fu #  1 , Jian-Long Li #  1 , Jia-Wei Chen  2 , Hao Liang  3 , Wen-Rui Zhao  4 , Shi-Yu He  5 , Xiao-Wei Ma  4 , Xiao-Fan Yang  4 , He-Lin Wang  6
Affiliations
Review

Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis

Chen-Fei Fu et al. Front Pharmacol. .

Abstract

Sepsis is a complex syndrome characterized by multi-organ dysfunction, due to the presence of harmful microorganisms in blood which could cause mortality. Complications associated with sepsis involve multiple organ dysfunction. The pathogenesis of sepsis remains intricate, with limited treatment options and high mortality rates. Traditional Chinese medicine (TCM) has consistently demonstrated to have a potential on various disease management. Its complements include reduction of oxidative stress, inhibiting inflammatory pathways, regulating immune responses, and improving microcirculation. Traditional Chinese medicine can mitigate or even treat sepsis in a human system. This review examines progress on the use of TCM extracts for treating sepsis through different pharmacological action and its mechanisms. The potential targets of TCM extracts and active ingredients for the treatment of sepsis and its complications have been elucidated through molecular biology research, network pharmacology prediction, molecular docking analysis, and visualization analysis. Our aim is to provide a theoretical basis and empirical support for utilizing TCM in the treatment of sepsis and its complications while also serving as a reference for future research and development of sepsis drugs.

Keywords: extracts; mechanism; pharmacological action; sepsis; traditional Chinese medicine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The mechanism actions in treatment of sepsis with TCM extracts involve the modulation of inflammatory imbalance, impaired immune function, and coagulation disorders.
FIGURE 2
FIGURE 2
The other mechanism actions in treatment of sepsis with TCM extracts.
FIGURE 3
FIGURE 3
The inflammatory imbalance process during sepsis.
See this image and copyright information in PMC

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