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Review
. 2024 Jun 19;10(12):e33307.
doi: 10.1016/j.heliyon.2024.e33307. eCollection 2024 Jun 30.

Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis

YiZheng Ma  1   2 , JingBo Han  3 , KangFeng Wang  2 , Huan Han  1   2 , YiBin Hu  1   2 , He Li  1   2 , ShengXian Wu  3 , LiJuan Zhang  2
Affiliations
Review

Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis

YiZheng Ma et al. Heliyon. .

Abstract

Atherosclerosis (AS) is a chronic inflammatory disease resulting from dysregulated lipid metabolism, constituting the pathophysiological foundation of cardiovascular and cerebrovascular diseases. AS has a high incidence rate and mortality rate worldwide. As such, traditional Chinese medicine (TCM) has been widely used recently due to its stable therapeutic effect and high safety. Ganoderma lucidum polysaccharides (GLP) are the main active ingredients of Ganoderma lucidum, a Chinese herbal medicine. Research has also shown that GLP has anti-inflammatory and antioxidant properties, regulates gut microbiota, improves blood glucose and lipid levels, and inhibits obesity. Most of the current research on GLP anti-AS is focused on animal models. Thus, its clinical application remains to be discovered. In this review, we combine relevant research results and start with the pathogenesis and risk factors of GLP on AS, proving that GLP can prevent and treat AS, providing a scientific basis and reference for the future prevention and treatment of AS with GLP.

Keywords: Atherosclerosis; Ganoderma lucidum polysaccharide; Intestinal flora; Obesity; Research progress.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
The main mechanism of GLP treating AS.
Fig. 2
Fig. 2
The primary mechanism of GLP in preventing AS.
See this image and copyright information in PMC

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