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. 2024 Jun 17;16(6):e62528.
doi: 10.7759/cureus.62528. eCollection 2024 Jun.

Sjogren's Antibodies and Neonatal Lupus: A Scoping Review

Deepika Nagliya  1 , Courteney Castellano  1 , Michelle L Demory  2 , Marc M Kesselman  3
Affiliations

Sjogren's Antibodies and Neonatal Lupus: A Scoping Review

Deepika Nagliya et al. Cureus. .

Abstract

Sjogren's syndrome (SS) is an autoimmune disease characterized by inflammation of exocrine glands. The disorder predominantly affects middle-aged women. Autoantibodies, including anti-SS-A/Ro and anti-SS-B/La antibodies, are present in most cases of SS. These antibodies can cross the placenta and likely play a role in pregnancy complications as well as the development of neonatal lupus, resulting in congenital heart block (CHB). It is essential to monitor the fetus for CHB during pregnancy. In particular, screening with echocardiography and monitoring heart rate at home are recommended practices. Regarding medical management, hydroxychloroquine and glucocorticoids have shown promise in reducing cardiac manifestations, but further research is needed to elucidate their longer term efficacy and safety. This scoping review analyzes literature from 2001 to 2024, focusing on pregnancy outcomes among women with SS, clinical manifestations of neonatal lupus, the role of anti-SS-A/Ro and anti-SS-B/La antibodies in the development of neonatal lupus and CHB, and emphasizes the need for future research efforts to refine treatment protocols and enhance clinical care strategies for pregnant women with SS.

Keywords: congenital heart block; fetal echocardiogram sjogren syndrome; hydroxychloroquine sjogren syndrome; neonatal lupus; sjogren syndrome and pregnancy; sjogren syndrome antibodies or ssa ssb; sjogren syndrome prenatal; stop bloq.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram
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References

    1. Novel aspects of Sjögren's syndrome in 2012. Tincani A, Andreoli L, Cavazzana I, et al. BMC Med. 2013;11:93. - PMC - PubMed
    1. Pathogenesis and treatment of Sjogren's syndrome: review and update. Zhan Q, Zhang J, Lin Y, Chen W, Fan X, Zhang D. Front Immunol. 2023;14:1127417. - PMC - PubMed
    1. Update on pathogenesis of Sjogren's syndrome. Sandhya P, Kurien BT, Danda D, Scofield RH. Curr Rheumatol Rev. 2017;13:5–22. - PMC - PubMed
    1. Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies. Brucato A, Cimaz R, Caporali R, Ramoni V, Buyon J. Clin Rev Allergy Immunol. 2011;40:27–41. - PMC - PubMed
    1. Pregnancy and autoimmune disease. Merz WM, Fischer-Betz R, Hellwig K, Lamprecht G, Gembruch U. Dtsch Arztebl Int. 2022;119:145–156. - PMC - PubMed

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