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Practice Guideline
. 2024 Nov;26(11):2826-2840.
doi: 10.1007/s12094-024-03600-7. Epub 2024 Jul 18.

SEOM-GEMCAD-TTD clinical guideline for the diagnosis and treatment of gastric cancer (2023)

Fernando Rivera  1 , Federico Longo  2 , Marta Martín Richard  3 , Paula Richart  4 , Maria Alsina  5 , Alberto Carmona  6 , Ana Belén Custodio  7 , Ana Fernández Montes  8 , Javier Gallego  9 , Tania Fleitas Kanonnikoff  10
Affiliations
Practice Guideline

SEOM-GEMCAD-TTD clinical guideline for the diagnosis and treatment of gastric cancer (2023)

Fernando Rivera et al. Clin Transl Oncol. 2024 Nov.

Abstract

Gastric cancer (GC) is the fifth most common cancer worldwide with a varied geographic distribution and an aggressive behavior. In Spain, the incidence is lower and GC represents the tenth most frequent tumor and the seventh cause of cancer mortality. Molecular biology knowledge allowed to better profile patients for a personalized therapeutic approach. In the localized setting, the multidisciplinary team discussion is fundamental for planning the therapeutic approach. Endoscopic resection in very early stage, perioperative chemotherapy in locally advanced tumors, and chemoradiation + surgery + adjuvant immunotherapy for the GEJ are current standards. For the metastatic setting, biomarker profiling including Her2, PD-L1, MSS status is needed. Chemotherapy in combination with checkpoint inhibitors had improved the outcomes for patients with PD-L1 expression. Her2 positive patients should receive antiHer2 therapy added to chemotherapy. We describe the different evidences and recommendations based on the literature.

Keywords: Gastric cancer; Immunotherapy; Precision medicine; Supportive care; Tumor biology.

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Conflict of interest statement

TFK reports being the speaker for Amgen, MSD, BMS, Roche and Bayer; being on the Advisory Board of MSD, AstraZeneca and Beigene; received Grant from GILEAD and Other from Lilly, MSD, Roche and BMS. FRH reports being on the Advisory Board, being a speaker, receiving Grant and non-financial support from MSD, AstraZeneca and Servier. He also reports being on the Advisory Board, being a speaker and receiving non-financial support from BMS, Astellas, Lilly and Roche; Advisory Board from Daiichi Sankyo; Advisory Board, speaker from Merck and Sanofi-Aventis and Advisory Board—Speaker—Grant from Amgen. AFM reports being on the Advisory Board, Speaker from BMS, MSD and Lilly. FLM reports being on the Advisory Board, being a speaker and other from Roche, Amgen, Servier, Lilly, BMS and MSD. MAM reports being on the Advisory Board from Amgen, AstraZeneca and Dragonfly Therapeutics; Advisory Board and Speaker from Beigene, Novartis, BMS and MSD; Speaker from Lilly and Grant from Merck. MMR reports personal feels from Amgen. JGP reports Advisory Board role and speaker from Elli Lilly, BMS and Servier; Advisory Board from MSD and Astellas and Other from AstraZeneca and other. ACB reports other from Merck and Speaker from BMS. ABCC and PARA have nothing to disclose.

Figures

Fig. 1
Fig. 1
Proposed algorithm for second and subsequent lines of treatment in advanced GC
See this image and copyright information in PMC

References

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