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Editorial
. 2024 Jul 19;135(3):450-452.
doi: 10.1161/CIRCRESAHA.124.324794. Epub 2024 Jul 18.

A New linc(-RNA) Between NFAT/MEF2 and Cardiac Hypertrophy

Chen Gao  1 , Yibin Wang  2   3
Affiliations
Editorial

A New linc(-RNA) Between NFAT/MEF2 and Cardiac Hypertrophy

Chen Gao et al. Circ Res. .
No abstract available

Keywords: Editorials; RNA, long noncoding; cardiomegaly; gene expression; hypertrophy; transcription factors.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1.
Figure 1.
Illustration of lincRNA-P21 mediated regulation of cardiac hypertrophy through interacting with KAP1 and subsequent regulation of NFAT-MEF2 dependent transcription. Made with Bio-Render
See this image and copyright information in PMC

Comment on

  • Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy.
    Wang Y, Zhang M, Wang R, Lin J, Ma Q, Guo H, Huang H, Liang Z, Cao Y, Zhang X, Lu YW, Liu J, Xiao F, Yan H, Dimitrova N, Huang ZP, Mably JD, Pu WT, Wang DZ. Wang Y, et al. Circ Res. 2024 Jul 19;135(3):434-449. doi: 10.1161/CIRCRESAHA.123.323356. Epub 2024 Jun 12. Circ Res. 2024. PMID: 38864216 Free PMC article.

References

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    1. Passier R, Zeng H, Frey N, Naya FJ, Nicol RL, McKinsey TA, Overbeek P, Richardson JA, Grant SR, Olson EN. CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo. J Clin Invest 2000;105:1395–1406. - PMC - PubMed
    1. Molkentin JD. Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs. Cardiovasc Res 2004;63:467–475. - PubMed
    1. Wang Yi, Zhang Mingming, Wang Rong, Lin Jing, Ma Qing, Guo Haipeng, Huang Huihui, Liang Zhuomin, Cao Yangpo, Zhang Xiaoran, et al. Therapeutic Inhibition of LincRNA-p21 Protects against Pathological Cardiac Hypertrophy by Selectively Suppressing Overactive NFAT/MEF2 Signaling. Circulation Research 2024; 135: xx–xxx. - PMC - PubMed
    1. McKinsey TA, Vondriska TM, Wang Y. Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. F1000Res 2018;7. - PMC - PubMed

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