Artemisinin-resistant malaria in Africa demands urgent action

Mehul Dhorda^{1

2}, Akira Kaneko³, Ryuichi Komatsu⁴, Achyut Kc³, Salum Mshamu⁵, Samwel Gesase⁶, Ntuli Kapologwe⁷, Ashenafi Assefa^{8

9}, Jimmy Opigo¹⁰, Yeka Adoke¹¹, Chris Ebong¹¹, Corine Karema¹², Aline Uwimana¹³, Jean-Louis Ndikumana Mangara¹³, Chanaki Amaratunga^{1

2}, Thomas J Peto^{1

2}, Rupam Tripura^{1

2}, James J Callery^{1

2}, Bipin Adhikari^{1

2}, Mavuto Mukaka^{1

2}, Phaik Yeong Cheah^{1

2}, Leon Mutesa¹⁴, Nicholas P J Day^{1

2}, Karen I Barnes¹⁵, Arjen Dondorp^{1

2}, Philip J Rosenthal¹⁶, Nicholas J White^{1

2}, Lorenz von Seidlein^{1

2}

Affiliations

¹ Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
² Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
³ Department of Microbiology, Tumor and Cell Biology (C1), Karolinska Institutet, Solna, Sweden.
⁴ Nagasaki University, Nagasaki, Japan.
⁵ CSK Research Solutions, Mtwara, Tanzania.
⁶ National Institute of Malaria Research, Tanga Medical Research Centre, Tanga, Tanzania.
⁷ Department of Preventive Health Services, Ministry of Health, Dodoma, Tanzania.
⁸ Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
⁹ Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
¹⁰ Ministry of Health, Kampala, Uganda.
¹¹ Infectious Diseases Research Collaboration, Kampala, Uganda.
¹² Quality & Equity Healthcare, Kigali, Rwanda.
¹³ Rwanda Biomedical Centre, Kigali, Rwanda.
¹⁴ Centre for Human Genetics, College of Medicine and Health Sciences University of Rwanda, Kigali, Rwanda.
¹⁵ Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
¹⁶ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Mehul Dhorda et al. Science. 2024.

. 2024 Jul 19;385(6706):252-254.

doi: 10.1126/science.adp5137. Epub 2024 Jul 18.

¹ Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
² Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
³ Department of Microbiology, Tumor and Cell Biology (C1), Karolinska Institutet, Solna, Sweden.
⁴ Nagasaki University, Nagasaki, Japan.
⁵ CSK Research Solutions, Mtwara, Tanzania.
⁶ National Institute of Malaria Research, Tanga Medical Research Centre, Tanga, Tanzania.
⁷ Department of Preventive Health Services, Ministry of Health, Dodoma, Tanzania.
⁸ Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
⁹ Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
¹⁰ Ministry of Health, Kampala, Uganda.
¹¹ Infectious Diseases Research Collaboration, Kampala, Uganda.
¹² Quality & Equity Healthcare, Kigali, Rwanda.
¹³ Rwanda Biomedical Centre, Kigali, Rwanda.
¹⁴ Centre for Human Genetics, College of Medicine and Health Sciences University of Rwanda, Kigali, Rwanda.
¹⁵ Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
¹⁶ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Abstract

Investment in community health workers is essential.