Is treatment-resistant schizophrenia a neuroimmune condition? Meta-analytic evidence from magnetic resonance spectroscopy

Affiliations

¹ Department of Psychiatry, University of California, Davis, CA, USA. jsmucny@ucdavis.edu.
² Department of Psychiatry, University of California, Irvine, CA, USA.

Jason Smucny et al. Neuropsychopharmacology. 2024 Nov.

. 2024 Nov;50(1):341-342.

doi: 10.1038/s41386-024-01932-0.

¹ Department of Psychiatry, University of California, Davis, CA, USA. jsmucny@ucdavis.edu.
² Department of Psychiatry, University of California, Irvine, CA, USA.

Erratum in

Correction: Neuropsychopharmacology Volume 50 Issue 1.
[No authors listed] [No authors listed] Neuropsychopharmacology. 2025 May;50(6):1019-1020. doi: 10.1038/s41386-025-02087-2. Neuropsychopharmacology. 2025. PMID: 40108440 Free PMC article. No abstract available.

No abstract available

The authors declare no competing interests.

1. Siskind D, Siskind V, Kisely S. Clozapine Response Rates among People with Treatment-Resistant Schizophrenia: Data from a Systematic Review and Meta-Analysis. Can J Psychiatry. 2017;62:772–7. - PMC - PubMed
1. de Bartolomeis A, Ciccarelli M, Vellucci L, Fornaro M, Iasevoli F, Barone A. Update on novel antipsychotics and pharmacological strategies for treatment-resistant schizophrenia. Expert Opin Pharmacother. 2022;23:2035–52. - PubMed
1. Potkin SG, Kane JM, Correll CU, Lindenmayer JP, Agid O, Marder SR, et al. The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research. Schizophrenia. 2020;6:1. - PMC - PubMed
1. Lesh TA, Maddock RJ, Howell A, Wang H, Tanase C, Daniel Ragland J, et al. Extracellular free water and glutathione in first-episode psychosis-a multimodal investigation of an inflammatory model for psychosis. Mol Psychiatry. 2021;26:761–71. - PMC - PubMed
1. Hu X, Zhou H, Zhang D, Yang S, Qian L, Wu HM, et al. Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation. J Neuroimmune Pharmacol. 2012;7:187–201. - PMC - PubMed