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. 2024 Jul 18;17(7):1307-1312.
doi: 10.18240/ijo.2024.07.16. eCollection 2024.

Early changes in corneal densitometry after FS-LASIK combined with accelerated corneal cross-linking for correction of high myopia

Qing-Bao Wang  1 , Hong-Sheng Bi  2   3 , Xiao-Fan Wang  1 , Hua Fan  2 , Li Li  1 , Peng Ji  2
Affiliations

Early changes in corneal densitometry after FS-LASIK combined with accelerated corneal cross-linking for correction of high myopia

Qing-Bao Wang et al. Int J Ophthalmol. .

Abstract

Aim: To observe the effects of femtosecond laser-assisted excimer laser in situ keratomileusis combined with accelerated corneal cross-linking (FS-LASIK Xtra) on corneal densitometry after correcting for high myopia.

Methods: In this prospectively study, 130 patients underwent FS-LASIK or FS-LASIK Xtra for high myopia. Their right eyes were selected for inclusion in the study, of which 65 cases of 65 eyes in the FS-LASIK group, 65 patients with 65 eyes in the FS-LASIK Xtra group. Patients were evaluated for corneal densitometry at 1, 3, and 6mo postoperatively using Pentacam Scheimpflug imaging.

Results: Preoperative differences in corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups in different ranges were not statistically significant (P>0.05). Layer-by-layer analysis revealed statistically significant differences in the anterior (120 µm), central, and total layer corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups at 1 and 3mo postoperatively (all P<0.05), the FS-LASIK Xtra group is higher than that of the FS-LASIK group. Analysis of different diameter ranges showed statistically significant differences between the FS-LASIK group and the FS-LASIK Xtra group at 1mo postoperatively in the ranges of 0-2, 2-6, and 6-10 mm (both P<0.05); At 3mo postoperatively, the FS-LASIK Xtra group is higher than that of the FS-LASIK group in the ranges of 0-2 and 2-6 mm (P<0.05). At 6mo postoperatively, there were no statistically significant differences in corneal densitometry between the FS-LASIK group and the FS-LASIK Xtra group in different diameter ranges (all P>0.05).

Conclusion: There is an increase in internal corneal densitometry during the early postoperative period after FS-LASIK Xtra for correction of high myopia. However, the densitometry values decreased to the level of conventional FS-LASIK at 6mo after surgery, with the most significant changes observed in the superficial central zone.

Keywords: accelerated corneal cross-linking; corneal densitometry; femtosecond laser; femtosecond laser in situ keratomileusis; high myopia.

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Conflict of interest statement

Conflicts of Interest: Wang QB, None; Bi HS, None; Wang XF, None; Fan H, None; Li L, None; Ji P, None.

Figures

Figure 1
Figure 1. Different diameters and different layers of densitometry.
Figure 2
Figure 2. A 24-year-old patient underwent FS-LASIK Xtra in July 2021
Highly reflective light in the superficial corneal stroma seen under slit-lamp in the early postoperative period. FS-LASIK Xtra: Femtosecond assisted laser in situ keratomileusis combined with accelerated corneal cross-linking.
Figure 3
Figure 3. Pentacam exams of the same patient preoperatively and at 1, 3, and 6mo postoperatively
FS-LASIK Xtra: Femtosecond assisted laser in situ keratomileusis combined with accelerated corneal cross-linking.
See this image and copyright information in PMC

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