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. 2024 Sep;271(9):6015-6024.
doi: 10.1007/s00415-024-12575-y. Epub 2024 Jul 19.

Temporalis muscle thickness as a predictor of functional outcome after reperfusion therapies for acute ischemic stroke: a retrospective, cohort study

Beatrice Ravera  1 , Chiara Lombardi  1 , Simone Bellavia  1 , Irene Scala  1 , Fabiana Cerulli  1 , Eleonora Torchia  1 , Sara Bortolani  2 , Pier Andrea Rizzo  1 , Giovanni Frisullo  2 , Aldobrando Broccolini  1   2 , Giacomo Della Marca  1   2 , Paolo Calabresi  1   2 , Mauro Monforte  3
Affiliations

Temporalis muscle thickness as a predictor of functional outcome after reperfusion therapies for acute ischemic stroke: a retrospective, cohort study

Beatrice Ravera et al. J Neurol. 2024 Sep.

Abstract

Background: Sarcopenia, defined as the loss of skeletal muscle mass, has been associated with a worse functional outcome after stroke. Measurement of temporal muscle thickness (TMT) has been introduced as an easily obtainable surrogate marker to identify patients with sarcopenia. Our study aims to investigate the correlation between pre-stroke sarcopenia, measured by TMT assessment, and functional outcome in patients treated with revascularization procedures for acute ischemic stroke.

Methods: We included consecutive adult patients who underwent thrombolysis, endovascular thrombectomy or both for acute ischemic stroke at our Centre from January 2020 to June 2022. Besides collecting baseline clinical and neuroradiological features, TMT was measured on brain computed tomography scans according to a standardized protocol. Modified Rankin Scale (mRS) scores at 3 months represented the main endpoint of functional outcome.

Results: A total of 261 patients were available for the analysis. In univariate models, patients with excellent outcomes (mRS = 0-1) were younger, had higher TMT values and lower pre-event disability and stroke severity. In multivariate models higher TMT values resulted independently associated with reduced mortality (Odds Ratio 0.708, 95% Confidence Interval 0.538-0.930, p = 0.013). Age, diabetes, brain bleeding events and stroke severity were found to be predictors of mortality, too.

Conclusions: Our retrospective analysis shows that in patients who underwent revascularization treatments for ischemic stroke TMT is as an independent predictor of survival easily obtainable from the baseline CT scan. Further investigation is required to confirm the role of sarcopenia assessment and TMT measurement in the prognostication toolkit of this disease.

Keywords: Endovascular thrombectomy; Ischemic stroke; Outcome; Sarcopenia; Temporalis muscle thickness; Thrombolysis.

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