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. 2024 Oct;60(5):559-562.
doi: 10.1007/s11262-024-02093-4. Epub 2024 Jul 19.

The complete genome of equid herpesvirus-1 (EHV-1) field isolates from Argentina reveals an interspecific recombinant strain

Rocio Lucia Tau #  1 , Ana Eugenia Marandino #  2 , Yanina Panzera  2 , Florencia Alamos  1   3 , Maria Aldana Vissani  1   3 , Sonia Alejandra Romera  1   3 , Ruben Pérez  2 , Silvina Soledad Maidana  4   5
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The complete genome of equid herpesvirus-1 (EHV-1) field isolates from Argentina reveals an interspecific recombinant strain

Rocio Lucia Tau et al. Virus Genes. 2024 Oct.

Abstract

The Equid alphaherpesvirus type 1 (EHV-1) infection can have devastating economic consequences in the horse industry due to large-scale outbreaks of abortions, perinatal foal mortality, and myeloencephalopathy. The present study analyzed the genome of two isolates obtained from aborted fetuses in Argentina, E/745/99 and E/1297/07. The E745/99 genome shares 98.2% sequence identity with Ab4, a reference EHV-1 strain. The E/1297/07 genome shares 99.8% identity with NY03, a recombinant strain containing part of ORF64 and part of the intergenic region from Equid alphaherpesvirus-4 (EHV-4). The E/1297/07 genome has the same breakpoints as other United States and Japanese recombinants, including NY03. The recombinant regions have varying numbers of tandem repeat sequences and different minor parental sequences (EHV-4), suggesting distinct origins of the recombinant events. These are the first complete genomes of EHV-1 from Argentina and South America available in the Databases.

Keywords: Argentina; Herpesvirus; Horse; ICP4; Recombination.

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