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. 2024 Jul 19;103(29):e38954.
doi: 10.1097/MD.0000000000038954.

Mapping the landscape: A bibliometric perspective on autophagy in spinal cord injury

Fei Wang  1 , Songou Zhang  2 , Yangjun Xu  3 , Wei He  1 , Xiang Wang  4 , Zhongwei He  3 , Jinxiang Shang  5 , Zhang Zhenyu  3
Affiliations

Mapping the landscape: A bibliometric perspective on autophagy in spinal cord injury

Fei Wang et al. Medicine (Baltimore). .

Abstract

Background: Spinal cord injury (SCI) is a severe condition that often leads to persistent damage of nerve cells and motor dysfunction. Autophagy is an intracellular system that regulates the recycling and degradation of proteins and lipids, primarily through lysosomal-dependent organelle degradation. Numerous publications have highlighted the involvement of autophagy in the secondary injury of SCI. Therefore, gaining a comprehensive understanding of autophagy research is crucial for designing effective therapies for SCI.

Methods: Dates were obtained from Web of Science, including articles and article reviews published from its inception to October 2023. VOSviewer, Citespace, and SCImago were used to visualized analysis. Bibliometric analysis was conducted using the Web of Science data, focusing on various categories such as publications, authors, journals, countries, organizations, and keywords. This analysis was aimed to summarize the knowledge map of autophagy and SCI.

Results: From 2009 to 2023, the number of annual publications in this field exhibited wave-like growth, with the highest number of publications recorded in 2020 (44 publications). Our analysis identified Mei Xifan as the most prolific author, while Kanno H emerged as the most influential author based on co-citations. Neuroscience Letters was found to have published the largest number of papers in this field. China was the most productive country, contributing 232 publications, and Wenzhou Medical University was the most active organization, publishing 39 papers.

Conclusion: We demonstrated a comprehensive overview of the relationship between autophagy and SCI utilizing bibliometric tools. This article could help to enhance the understanding of the field about autophagy and SCI, foster collaboration among researchers and organizations, and identify potential therapeutic targets for treatment.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Publication screening flowchart.
Figure 2.
Figure 2.
Annual output of autophagy in SCI. SCI = spinal cord injury.
Figure 3.
Figure 3.
The visualization of authors (A) and co-cited authors (B) on research of autophagy in SCI. SCI = spinal cord injury.
Figure 4.
Figure 4.
The visualization of journals (A, B) and co-cited journals (C) on research of autophagy in SCI. SCI = spinal cord injury.
Figure 5.
Figure 5.
The visualization of country (A and B) and organization (C–E) on research of autophagy in SCI. SCI = spinal cord injury.
Figure 6.
Figure 6.
The visualization of co-cited reference.
Figure 7.
Figure 7.
The visualization of keywords (A, B, C) and keywords burst (D).
See this image and copyright information in PMC

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References

    1. GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:56–87. - PMC - PubMed
    1. Saadoun S, Papadopoulos MC. Targeted perfusion therapy in spinal cord trauma. Neurotherapeutics. 2020;17:511–21. - PMC - PubMed
    1. Li F, Wang H, Chen H, et al. . Mechanism of ferroptosis and its role in spinal cord injury. Front Neurol. 2022;13:926780. - PMC - PubMed
    1. Park CS, Lee JY, Choi HY, Ju BG, Youn I, Yune TY. Protocatechuic acid improves functional recovery after spinal cord injury by attenuating blood-spinal cord barrier disruption and hemorrhage in rats. Neurochem Int. 2019;124:181–92. - PubMed
    1. Lin S, Mei X. Role of NLRP3 inflammasomes in neuroinflammation diseases. Eur Neurol. 2021;83:576–80. - PubMed