Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist

Siew S Lim¹, Zhila Semnani-Azad², Mario L Morieri^{3

4}, Ashley H Ng^{5

6

7}, Abrar Ahmad⁸, Hugo Fitipaldi⁸, Jacqueline Boyle¹, Christian Collin⁹, John M Dennis¹⁰, Claudia Langenberg^{7

11}, Ruth J F Loos^{12

13}, Melinda Morrison¹⁴, Michele Ramsay¹⁵, Arun J Sanyal¹⁶, Naveed Sattar¹⁷, Marie-France Hivert¹⁸, Maria F Gomez⁸, Jordi Merino^{12

19

20

21}, Deirdre K Tobias^{2

22}, Michael I Trenell²³, Stephen S Rich²⁴, Jennifer L Sargent²⁵, Paul W Franks^{26

27}

Affiliations

¹ Health Systems and Equity, Eastern Health Clinical School, Monash University, Box Hill, Victoria, Australia.
² Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
³ Unit of Metabolic Disease, University-Hospital of Padua, Padua, Italy.
⁴ Department of Medicine, University of Padua, Padua, Italy.
⁵ Monash Centre for Health Research Implementation, Monash University and Monash Health, Melbourne, Victoria, Australia.
⁶ Monash Partners Academic Health Science Centre, Melbourne, Victoria, Australia.
⁷ Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.
⁸ Diabetic Complications Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Malmo, Sweden.
⁹ Board of Directors, Steno Diabetes Center, Copenhagen, Denmark.
¹⁰ Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.
¹¹ Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
¹² Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
¹³ Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹⁴ Diabetes Australia, Canberra, Australian Capital Territory, Australia.
¹⁵ Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa.
¹⁶ Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
¹⁷ School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
¹⁸ Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
¹⁹ Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.
²⁰ Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
²¹ Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
²² Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
²³ Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
²⁴ Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
²⁵ School of Public Health, Imperial College London, London, UK.
²⁶ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. paul.franks@med.lu.se.
²⁷ Department of Clinical Sciences, Lund University, Helsingborg, Sweden. paul.franks@med.lu.se.

PMID: 39030405
DOI: 10.1038/s41591-024-03033-3

Review

Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist

Siew S Lim et al. Nat Med. 2024 Jul.

. 2024 Jul;30(7):1874-1881.

doi: 10.1038/s41591-024-03033-3. Epub 2024 Jul 19.

Authors

Affiliations

¹ Health Systems and Equity, Eastern Health Clinical School, Monash University, Box Hill, Victoria, Australia.
² Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
³ Unit of Metabolic Disease, University-Hospital of Padua, Padua, Italy.
⁴ Department of Medicine, University of Padua, Padua, Italy.
⁵ Monash Centre for Health Research Implementation, Monash University and Monash Health, Melbourne, Victoria, Australia.
⁶ Monash Partners Academic Health Science Centre, Melbourne, Victoria, Australia.
⁷ Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.
⁸ Diabetic Complications Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Malmo, Sweden.
⁹ Board of Directors, Steno Diabetes Center, Copenhagen, Denmark.
¹⁰ Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.
¹¹ Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
¹² Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
¹³ Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹⁴ Diabetes Australia, Canberra, Australian Capital Territory, Australia.
¹⁵ Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa.
¹⁶ Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
¹⁷ School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
¹⁸ Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
¹⁹ Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.
²⁰ Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
²¹ Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
²² Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
²³ Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
²⁴ Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
²⁵ School of Public Health, Imperial College London, London, UK.
²⁶ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. paul.franks@med.lu.se.
²⁷ Department of Clinical Sciences, Lund University, Helsingborg, Sweden. paul.franks@med.lu.se.

PMID: 39030405
DOI: 10.1038/s41591-024-03033-3

Abstract

Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reporting, this heterogeneity, combined with the diversity of research tools used in precision medicine studies, makes comparisons across studies and implementation of the findings challenging. Specific recommendations for reporting precision medicine research do not currently exist. The BePRECISE (Better Precision-data Reporting of Evidence from Clinical Intervention Studies & Epidemiology) consortium, comprising 23 experts in precision medicine, cardiometabolic diseases, statistics, editorial and lived experience, conducted a scoping review and participated in a modified Delphi and nominal group technique process to develop guidelines for reporting precision medicine research. The BePRECISE checklist comprises 23 items organized into 5 sections that align with typical sections of a scientific publication. A specific section about health equity serves to encourage precision medicine research to be inclusive of individuals and communities that are traditionally under-represented in clinical research and/or underserved by health systems. Adoption of BePRECISE by investigators, reviewers and editors will facilitate and accelerate equitable clinical implementation of precision medicine.

PubMed Disclaimer

References

1. Chung, W. K. et al. Precision medicine in diabetes: a consensus report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 43, 1617–1635 (2020). - DOI - PubMed - PMC
1. Chung, W. K. et al. Precision medicine in diabetes: a consensus report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 63, 1671–1693 (2020). - DOI - PubMed - PMC
1. Tobias, D. K. et al. Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine. Nat. Med. 29, 2438–2457 (2023). - DOI - PubMed - PMC
1. GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396, 1204–1222 (2020). - DOI
1. Sun, H. et al. IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res. Clin. Pract. 183, 109119 (2022). - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- Nature Publishing Group

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist

Affiliations

Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources