Skin longevity: A paradigm shift in aesthetics

Saranya Wyles¹, Rahul Mehta², Joan Mannick³, Doris Day^{4

5}

Affiliations

¹ Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
² Rapalogix Health Inc., New York, New York, USA.
³ Tornado Therapeutics, New York, New York, USA.
⁴ Department of Dermatology, New York University Langone Medical Center, New York, New York, USA.
⁵ Day Dermatology and Aesthetics, New York, New York, USA.

Editorial

Saranya Wyles et al. J Cosmet Dermatol. 2024 Sep.

. 2024 Sep;23(9):2814-2815.

doi: 10.1111/jocd.16484. Epub 2024 Jul 18.

Saranya Wyles¹, Rahul Mehta², Joan Mannick³, Doris Day^{4

5}

¹ Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
² Rapalogix Health Inc., New York, New York, USA.
³ Tornado Therapeutics, New York, New York, USA.
⁴ Department of Dermatology, New York University Langone Medical Center, New York, New York, USA.
⁵ Day Dermatology and Aesthetics, New York, New York, USA.

No abstract available

References

1. Lopez‐Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186(2):243‐278. doi:10.1016/j.cell.2022.11.001
1. Wyles SP, Carruthers JD, Dashti P, et al. Cellular senescence in human skin aging: leveraging senotherapeutics. Gerontology. 2024;70(1):7‐14. doi:10.1159/000534756
1. Franco AC, Aveleira C, Cavadas C. Skin senescence: mechanisms and impact on whole‐body aging. Trends Mol Med. 2022;28(2):97‐109. doi:10.1016/j.molmed.2021.12.003
1. Mannick JB, Lamming DW. Targeting the biology of aging with mTOR inhibitors. Nat Aging. 2023;3(6):642‐660. doi:10.1038/s43587-023-00416-y
1. Chung CL, Lawrence I, Hoffman M, et al. Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial. Geroscience. 2019;41(6):861‐869. doi:10.1007/s11357-019-00113-y