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Comment
. 2024 Aug;106(2):185-188.
doi: 10.1016/j.kint.2024.05.022.

DNA-binding protein-A: a multitool in tubular epithelial cells

Patrick Droste  1 , Peter Boor  1 , Roman D Bülow  2
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DNA-binding protein-A: a multitool in tubular epithelial cells

Patrick Droste et al. Kidney Int. 2024 Aug.

Abstract

Acute kidney injury is still associated with high morbidity and mortality. Reichardt et al. investigated DNA-binding protein-A (Ybx3) in acute kidney injury induced by ischemia-reperfusion injury and found that mice lacking Ybx3 have altered mitochondrial function and increased antioxidant activity, making them more resistant to ischemia-reperfusion injury-acute kidney injury. The study highlights a new role of the multifaceted protein DNA-binding protein-A, which could be potentially therapeutically exploited.

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