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Review
. 2024 Oct;38(10):728-730.
doi: 10.1038/s41371-024-00935-0. Epub 2024 Jul 20.

"Deeds not words": the forgotten class

Affiliations
Review

"Deeds not words": the forgotten class

Bernadette Jenner. J Hum Hypertens. 2024 Oct.

Abstract

The Sir Stanley Peart Essay Competition is an annual event run by the British and Irish Hypertension Society to encourage Early Career Researchers to continue the ethos of Sir Stanley Peart. Sir Stanley Peart was a clinician and clinical researcher who made a major contribution to our understanding of blood pressure regulation. He was the first to demonstrate the release of noradrenaline in response to sympathetic nerve stimulation. He was also the first to purify, and determine the structure of, angiotensin and he later isolated the enzyme, renin, and carried out many important investigations of the factors controlling its release in the body. This year, the essay topic was "Do we need new classes of antihypertensive drugs?". In her prize-winning essay, "Deeds not words": the forgotten class, Dr Jenner proposes that there is a need to address the unmet needs of hypertensive women, to increase their involvement in clinical trials and develop antihypertensives that are fit for purpose. Dr Jenner proposes that women are therefore the perfect class for new antihypertensives.

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Conflict of interest statement

Professor Phil Chowienczyk has an interest in Centron Diagnostics, a company that has produced technology for blood pressure measurement. Professor Ian B Wilkinson has received research grants from AstraZeneca, GSK and scientific advisory board consultation fees for Viatris, Astra Zeneca and Roche. BJ, Dr Sarah Partridge and Professor Peter Sever have no competing interests to declare for this manuscript.

References

    1. Institute for Health Metrics and Evaluation (IHME). Global Burden of Disease 2021: Findings from the GBD 2021 Study. Seattle, WA: IHME; 2024.
    1. Gerdts E, Sudano I, Brouwers S, Borghi C, Bruno RM, Ceconi C, et al. Sex differences in arterial hypertension. Eur Heart J. 2022;43:4777–88. - PMC - PubMed
    1. Haug EB, Horn J, Markovitz AR, Fraser A, Vatten LJ, Macdonald‐Wallis C, et al. Life course trajectories of cardiovascular risk factors in women with and without hypertensive disorders in first pregnancy: the HUNT Study in Norway. JAHA. 2018;7:e009250. - PMC - PubMed
    1. Wojczakowski W, Kimber-Trojnar Ż, Dziwisz F, Słodzińska M, Słodziński H, Leszczyńska-Gorzelak B. Preeclampsia and cardiovascular risk for offspring. JCM. 2021;10:3154. - PMC - PubMed
    1. Kotchen TA. Historical trends and milestones in hypertension research: a model of the process of translational research. Hypertension. 2011;58:522–38. - PubMed

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