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. 2024 Sep;242(9):2241-2247.
doi: 10.1007/s00221-024-06893-w. Epub 2024 Jul 22.

Effects of early monocular enucleation on cortical spreading depression in well-nourished and malnourished adult rats

Rubem Carlos Araujo Guedes  1 , Jailma Santos Monteiro  1 , Silvio de Biase  1 , Ana Paula Rocha de Melo  1 , Juliana Maria Carrazzone Borba  1 , Cristovam Wanderley Picanço Diniz  2 , Arthur Gabriel Alves Furtado de Carvalho Noya  3 , Sonia Carolina Guerrero Prieto  4
Affiliations

Effects of early monocular enucleation on cortical spreading depression in well-nourished and malnourished adult rats

Rubem Carlos Araujo Guedes et al. Exp Brain Res. 2024 Sep.

Abstract

Sensory development is a complex process that can influence physiological and pathological factors. In laterally-eyed mammals, monocular enucleation (ME) during development and the subsequent lack of external sensory stimuli can result in permanent morphological and physiological changes. Malnutrition, especially in early life, also can cause permanent morphofunctional changes due to inadequate nutrient intake in both hemispheres. This study investigated the effects of early (postnatal day 7) ME and malnutrition during the suckling period on cortical excitability in adulthood (110-140 days of life). For this, we compared the speed propagation of cortical spreading depression in the occipital and parietal cortex of malnourished and well-nourished adult rats, previously suckled small-sized litters with three pups (L3/dam) medium-sized litters with six pups (L6/dam), and large-sized litters with twelve pups (L12/dam). The CSD velocity was augmented by the ME in the contralateral side of the removed eye in the parietal and occipital cortex. These findings suggest that visual sensory input deprivation is associated with permanent functional changes in the visual pathways, which can alter cortical excitability and lead to modifications in CSD propagation.

Keywords: Cortical spreading depression; Enucleation; Malnutrition; Sensory deafferentation.

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