Ethical concerns in aging research: perspectives of global frontline researchers

Yaojin Peng^#^{1

2

3

4

5}, Lulu Ding^#^{6

7}, Zhenyu Xiao^#⁸, Moshi Song^#^{6

9

10

7

11}, Jianwei Lv¹², Guang-Hui Liu^{13

14

15

16

17

18

19}

Affiliations

¹ Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
² University of Chinese Academy of Sciences, Beijing, 100049, China. yaojin.peng@ioz.ac.cn.
³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
⁵ Aging Biomarker Consortium (ABC), Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
⁶ Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
⁸ School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
⁹ University of Chinese Academy of Sciences, Beijing, 100049, China.
¹⁰ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
¹¹ Aging Biomarker Consortium (ABC), Beijing, 100101, China.
¹² School of Life Sciences, Xiamen University, Xiamen, 361102, China.
¹³ Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.
¹⁵ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁶ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁷ Aging Biomarker Consortium (ABC), Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁸ Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.
¹⁹ Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.

^# Contributed equally.

PMID: 39034350
DOI: 10.1007/s11427-024-2650-y

Ethical concerns in aging research: perspectives of global frontline researchers

Yaojin Peng et al. Sci China Life Sci. 2024 Oct.

. 2024 Oct;67(10):2149-2156.

doi: 10.1007/s11427-024-2650-y. Epub 2024 Jul 19.

Authors

Yaojin Peng^#^{1

2

3

4

5}, Lulu Ding^#^{6

7}, Zhenyu Xiao^#⁸, Moshi Song^#^{6

9

10

7

11}, Jianwei Lv¹², Guang-Hui Liu^{13

14

15

16

17

18

19}

Affiliations

¹ Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
² University of Chinese Academy of Sciences, Beijing, 100049, China. yaojin.peng@ioz.ac.cn.
³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
⁵ Aging Biomarker Consortium (ABC), Beijing, 100101, China. yaojin.peng@ioz.ac.cn.
⁶ Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
⁸ School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
⁹ University of Chinese Academy of Sciences, Beijing, 100049, China.
¹⁰ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
¹¹ Aging Biomarker Consortium (ABC), Beijing, 100101, China.
¹² School of Life Sciences, Xiamen University, Xiamen, 361102, China.
¹³ Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.
¹⁵ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁶ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁷ Aging Biomarker Consortium (ABC), Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁸ Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.
¹⁹ Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.

^# Contributed equally.

PMID: 39034350
DOI: 10.1007/s11427-024-2650-y

Abstract

This study investigated the ethical landscape of aging research amid the increasing global focus on extending the human lifespan and health span. Our global survey of 180 researchers across 38 jurisdictions revealed divergent perceptions of aging, a consensus regarding the feasibility of delaying aging, and multiple perspectives regarding lifespan extension. The present findings underscore a paradigm shift toward inclusive and ethically sound research, emphasizing the need for an approach that strikes a balance between basic and clinical research. In addition, this study highlighted key ethical concerns in aging research, including the effects of misleading advertising, potential inequality in access to aging interventions, and risks pertaining to the extrapolation of research findings from lower-model organisms to humans. The insights presented in this paper call for an integrated approach for overcoming the complex ethical and societal challenges in aging research to ensure responsible and equitable advancements in this burgeoning field.

Keywords: aging; ethical landscape; ethics; surveys and questionnaires.

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References

1. Aging Biomarker Consortium, Bao, H., Cao, J., Chen, M., Chen, M., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., et al. (2023a). Biomarkers of aging. Sci China Life Sci 66, 893–1066. - PMC
1. Aging Biomarker Consortium, Jia, Y.J., Wang, J., Ren, J.R., Chan, P., Chen, S., Chen, X.C., Chhetri, J.K., Guo, J., Guo, Q., et al. (2023b). A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium. Life Med 2, lnad017. - PMC
1. Aging Biomarker Consortium, Jiang, M., Zheng, Z., Wang, X., Chen, Y., Qu, J., Ding, Q., Zhang, W., Liu, Y.S., Yang, J., et al. (2024). A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement. Life Med 3, lnae004. - PMC
1. Aging Biomarker Consortium, Suo, J., Gan, Y., Xie, Y., Xu, S., Wang, J., Chen, D., Chen, L., Deng, L., Feng, S., et al. (2023c). A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium. Life Med 2, lnad045. - PMC
1. Aging Biomarker Consortium, Zhang, L., Guo, J., Liu, Y., Sun, S., Liu, B., Yang, Q., Tao, J., Tian, X.L., Pu, J., et al. (2023d). A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium. Life Med 2, lnad033. - PMC

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Ethical concerns in aging research: perspectives of global frontline researchers

Affiliations

Ethical concerns in aging research: perspectives of global frontline researchers

Authors

Affiliations

Abstract

References

MeSH terms

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Full Text Sources

Medical

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