Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Jul 1;23(3):494-495.
doi: 10.4103/aam.aam_161_23. Epub 2024 Jul 20.

Pyrazinamide-induced Toxic Epidermal Necrolysis

[Article in French, English]
Ananda Datta  1 , Raghavendrun Sivasankar  1 , Bikash Ranjan Kar  2
Affiliations
Case Reports

Pyrazinamide-induced Toxic Epidermal Necrolysis

[Article in French, English]
Ananda Datta et al. Ann Afr Med. .

Abstract
in English, French, French

The antitubercular drugs are associated with different cutaneous adverse drug reactions. Toxic epidermal necrolysis (TEN) is a severe form of cutaneous reaction. Although it is rare, it carries a high mortality rate. We report a case of a 75-year-old man with abdominal tuberculosis, who developed pyrazinamide-induced TEN.

RésuméLes médicaments antituberculeux sont associés à différents effets indésirables cutanés. La nécrolyse épidermique toxique (TEN) est une forme sévère de réaction cutanée. Bien qu’elle soit rare, elle entraîne un taux de mortalité élevé. Nous rapportons le cas d’un homme de 75 ans atteint de tuberculose abdominale, qui ont développé un TEN induit par le pyrazinamide.

Les médicaments antituberculeux sont associés à différents effets indésirables cutanés. La nécrolyse épidermique toxique (TEN) est une forme sévère de réaction cutanée. Bien qu’elle soit rare, elle entraîne un taux de mortalité élevé. Nous rapportons le cas d’un homme de 75 ans atteint de tuberculose abdominale, qui ont développé un TEN induit par le pyrazinamide.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
The photograph showing the presence of multiple erythematous purpuric macules on the back (a), the macules coalesced to form sheets of erythematous patches on the lower limbs. There is also the presence of excoriated bullae (b)
See this image and copyright information in PMC

References

    1. Jin HJ, Kang DY, Nam YH, Ye YM, Koh YI, Hur GY, et al. Severe cutaneous adverse reactions to anti-tuberculosis drugs in Korean patients. Allergy Asthma Immunol Res. 2021;13:245–55. - PMC - PubMed
    1. Frantz R, Huang S, Are A, Motaparthi K. Stevens-Johnson syndrome and toxic epidermal necrolysis: A review of diagnosis and management. Medicina (Kaunas) 2021;57:895. - PMC - PubMed
    1. Peter J, Lehloenya RJ. Cutaneous adverse drug reactions from antituberculosis treatment. In: Shear N, Dodiuk-Gad R, editors. Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions current and future trends. Singapore: Adis; 2019. pp. 207–15.

Publication types

LinkOut - more resources