Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025;19(3):434-452.
doi: 10.2174/0118722105296316240626071243.

Cutting-Edge Developments and Patent Trends in Microspheres Drug Delivery: A Comprehensive Overview

Affiliations
Review

Cutting-Edge Developments and Patent Trends in Microspheres Drug Delivery: A Comprehensive Overview

Shailesh Sharma et al. Recent Pat Nanotechnol. 2025.

Abstract

Microspheres have emerged as innovative drug delivery platforms with significant potential to improve the therapeutic efficacy of drugs with limited aqueous solubility and prolong their release. This abstract provides an overview of recent developments and patents granted in microsphere research, highlighting key trends and innovative approaches. Recent studies have focused on various aspects of microspheres, including formulation techniques, materials selection, and their applications in drug delivery. Recent breakthroughs in polymer science have paved the way for the creation of innovative biodegradable and biocompatible materials for microsphere fabrication, improving drug encapsulation effectiveness and release dynamics. Notably, the integration of nanomaterials and functionalized polymers has enabled precise control over drug release rates and enhanced targeting capabilities. The utilization of microspheres for administering a diverse array of therapeutic substances, including anticancer drugs, anti-inflammatory agents, and peptides, has gained significant attention. These microspheres have demonstrated the potential to enhance drug stability, minimize dosing frequency and enhance patient adherence.

Keywords: Microsphere; anticancer drugs; drug delivery.; drug stability; microparticle; types of microsphere.

PubMed Disclaimer

Similar articles

References

    1. Gurung B.D.; Kakar S.; An overview on microspheres. Int J Health Clin Res 2020,3(1),11-24
    1. Noguez Méndez N.A.; Quirino Barreda C.T.; Vega A.F.; Miranda Calderon J.E.; Urioste C.G.; Palomec X.C.; Martinez A.R.; Díaz M.P.; Design and development of pharmaceutical microprocesses in the production of nanomedicine. Nanostructures for Oral Medicine: Micro and Nano Technologies 2017,669-697 - DOI
    1. Yandrapu S.; Kompella U.B.; Development of sustained-release microspheres for the delivery of SAR 1118, an LFA-1 antagonist intended for the treatment of vascular complications of the eye. J Ocul Pharmacol Ther 2013,29(2),236-248 - DOI - PubMed
    1. Singh C.; Purohit S.; Singh M.; Pandey B.L.; Design and evaluation of microspheres: A Review. J Drug Deliv Res 2013,2(1),22-24
    1. Gavali K.V.; Kengar M.D.; Chavan K.V.; Anekar V.P.; Khan N.I.; A review on microsphere and it’s application. Asian J Pharmaceut Res 2019,9(2),123-129 - DOI

LinkOut - more resources