Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 8;5(1):546-553.
doi: 10.1089/whr.2023.0080. eCollection 2024.

Diagnostic Accuracy of Combined 3.0T Magnetic Resonance Imaging and Molybdenum Target X-Ray in Triple-Negative Breast Cancer: Correlation with Prognosis in Patients Undergoing Sentinel Lymph Node Biopsy

Li Xia  1 , Ling Yang  1 , Meng Hu  1
Affiliations

Diagnostic Accuracy of Combined 3.0T Magnetic Resonance Imaging and Molybdenum Target X-Ray in Triple-Negative Breast Cancer: Correlation with Prognosis in Patients Undergoing Sentinel Lymph Node Biopsy

Li Xia et al. Womens Health Rep (New Rochelle). .

Abstract

Objective: This study assessed the diagnostic efficacy of combining 3.0T MRI and molybdenum target X-ray in triple-negative breast carcinoma (TNBC) and its association with the prognosis of sentinel lymph node biopsy (SLNB).

Methods: The retrospective analysis included 128 patients suspected of having TNBC, who underwent 3.0T MRI and molybdenum target X-ray. Sensitivity and specificity were calculated for each imaging technique, and their combined diagnosis was evaluated using the four-table method. Consistency between the imaging techniques and pathological examination was assessed using the consistency checking method. Additionally, changes in imaging indicators were compared among patients with different prognostic indicators.

Results: Among the 128 patients, 86 were diagnosed with TNBC through pathological examination. The sensitivity and specificity of 3.0T MRI for TNBC were 82.56% and 76.19%, respectively. Molybdenum target X-ray exhibited a sensitivity of 77.91% and specificity of 78.57%. The combined diagnosis of the two techniques showed a sensitivity of 90.70% and specificity of 86.36%. There was good agreement between both imaging techniques and pathological examination results. Significant differences were observed in imaging indicators based on tumor diameter, histological grade, and lymph node metastasis.

Conclusion: Both 3.0T MRI and molybdenum target X-ray are valuable in diagnosing TNBC. Additionally, these imaging techniques provide prognostic information and can aid in treatment decision-making. The findings highlight the importance of 3.0T MRI and molybdenum target X-ray in improving the outcomes of patients with TNBC.

Keywords: 3.0T magnetic resonance imaging; Correlation; Diagnosis; Molybdenum target X-ray; Prognosis; Triple-negative breast cancer.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Analysis of the relationship between 3.0T MRI indicators and the largest diameter of TNBC tumors. (A) is the analysis of the relationship between 3.0T MRI Ktrans indexes and the largest diameter of TNBC tumors; (B) is the analysis of the relationship between 3.0T MRI Kep indexes and the largest diameter of TNBC tumors; (C) is the analysis of the relationship between 3.0T MRI ADC indexes and the largest diameter of TNBC tumors.
FIG. 2.
FIG. 2.
Analysis of the relationship between 3.0T MRI indicators and TNBC histological grade. (A) is the analysis of the relationship between 3.0T MRI Ktrans indexes and TNBC histological grade; (B) is the analysis of the relationship between 3.0T MRI Kep indexes and TNBC histological grade; (C) is the analysis of the relationship between 3.0T MRI ADC indexes and TNBC histological grade.
FIG. 3.
FIG. 3.
Analysis of the relationship between 3.0T MRI indicators and TNBC lymph node metastasis. (A) is the analysis of the relationship between 3.0T MRI Ktrans indexes and TNBC lymph node metastasis; (B) is the analysis of the relationship between 3.0T MRI Kep indexes and TNBC lymph node metastasis; (C) is the analysis of the relationship between 3.0T MRI ADC indexes and TNBC lymph node metastasis.
See this image and copyright information in PMC

References

    1. Howard FM, Olopade OI. Epidemiology of triple-negative breast cancer: A review. Cancer J 2021;27(1):8–16. - PubMed
    1. Won KA, Spruck C. Triple-negative breast cancer therapy: Current and future perspectives (Review). Int J Oncol 2020;57(6):1245–1261. - PMC - PubMed
    1. Bardia A, Hurvitz SA, Tolaney SM, et al. . Sacituzumab govitecan in metastatic triple-negative breast cancer. N Engl J Med 2021;384(16):1529–1541. - PubMed
    1. Derakhshan F, Reis-Filho JS. Pathogenesis of triple-negative breast cancer. Annu Rev Pathol 2022;17:181–204. - PMC - PubMed
    1. Kim JH, Park VY, Shin HJ, et al. . Ultrafast dynamic contrast-enhanced breast MRI: Association with pathologic complete response in neoadjuvant treatment of breast cancer. Eur Radiol 2022;32(7):4823–4833. - PubMed

LinkOut - more resources