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. 2022 Jul 22;2(3):132-138.
doi: 10.1016/j.jncc.2022.07.002. eCollection 2022 Sep.

Survival of patients with gastric cancer surgically treated at the National Cancer Center of China from 2011 to 2018 according to stage at diagnosis

Wenzhe Kang  1 , Hongmei Zeng  2 , Jianping Xiong  1 , Yang Li  1 , Peng Jin  1 , Xinxin Shao  1 , Haitao Hu  1 , Bingzhi Wang  3 , Yibin Xie  1   4 , Yantao Tian  1
Affiliations

Survival of patients with gastric cancer surgically treated at the National Cancer Center of China from 2011 to 2018 according to stage at diagnosis

Wenzhe Kang et al. J Natl Cancer Cent. .

Abstract

Objective: The postoperative survival rates of patients with gastric cancer at different stages treated at the National Cancer Center (NCC) of China have not been reported. Therefore, we evaluated the survival of patients with gastric cancer who underwent surgery at the NCC from 2011 to 2018 to provide baseline information for further studies.

Methods: We identified 7,301 patients with primary gastric carcinoma who underwent surgery at the NCC between January 2011 and May 2018; among these, 5,008 patients were enrolled in this study. Follow up was completed on April 30, 2020. We analyzed the 5-year survival according to the stage, sex, age, and other clinicopathological features.

Results: Five-year survival rates of patients with pTNM stages IA, IB, IIA, IIB, IIIA, IIIB, IIIC, and IV treated at the NCC were 94.9%, 91.8%, 86.5%, 76.1%, 61.1%, 44.2%, 29.7%, and 8.1%, respectively, which were similar to those reported in Japan during the same period. Five-year survival rates of patients with ypTNM stages I, II, III, and IV were 93.1%, 63.2%, 27.2%, and 0.0%, respectively. In multivariable analysis, age, signet ring cell carcinoma, adjuvant chemotherapy, and degree of differentiation were revealed as important prognostic factors.

Conclusion: The survival rates of patients with gastric cancer treated at the NCC have been significantly improved, reaching the levels of Japan in the same period.

Keywords: 5-year survival rate; Gastric cancer; National Cancer Center; Survival.

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Conflict of interest statement

The authors declare that they have no conflict of interests.

Figures

Fig 1
Fig. 1
Flowchart of patient selection.
Fig 2
Fig. 2
Kaplan–Meier survival curves of patients stratified to various subsets of stages. (A) Overall survival for patients without neoadjuvant chemotherapy. (B) Overall survival for patients with ypTNM stages. (C) Overall survival for patients with pTNM stages. OS, overall survival; ypTNM, post-neoadjuvant therapy stage.
Fig 3
Fig. 3
(A) The comparison in 5-year survival rates of patients with pTNM between the NCC and Japan according to stage. (B) The comparison in 5-year survival rates of patients with pTNM between the NCC and IGCA according to stage. (C) The comparison in 5-year survival rates between patients with pTNM and ypTNM in the NCC according to stage. (D) The comparison in 5-year survival rates of patients with ypTNM between the NCC and NCBD according to stage. IGCA, International Gastric Cancer Association; NCBD, National Cancer Database; NCC, National Cancer Center of China; ypTNM, post-neoadjuvant therapy stage.
See this image and copyright information in PMC

References

    1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–132. doi: 10.3322/caac.21338. - DOI - PubMed
    1. Zeng H, Chen W, Zheng R, et al. Changing cancer survival in China during 2003–15: a pooled analysis of 17 population-based cancer registries. Lancet Glob Health. 2018;6(5):e555–e567. doi: 10.1016/S2214-109X(18)30127-X. - DOI - PubMed
    1. Suzuki S, Takahashi A, Ishikawa T, et al. Surgically treated gastric cancer in Japan: 2011 annual report of the national clinical database gastric cancer registry. Gastric Cancer. 2021;24(3):545–566. doi: 10.1007/s10120-021-01178-5. - DOI - PubMed
    1. Zeng H, Zheng R, Guo Y, et al. Cancer survival in China, 2003-2005: a population-based study. Int J Cancer. 2015;136:1921–1930. doi: 10.1016/j.canlet.2015.04.021. - DOI - PubMed

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