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Case Reports
. 2024 May 19:50:6-8.
doi: 10.1016/j.jdcr.2024.05.016. eCollection 2024 Aug.

Generalized pustular psoriasis successfully treated with spesolimab in the setting of metastatic colon cancer

Diamond Rose Guy  1 , Sydney DeVore  2 , Vatsala Kirtani  3 , Nananamibia Duffy  4
Affiliations
Case Reports

Generalized pustular psoriasis successfully treated with spesolimab in the setting of metastatic colon cancer

Diamond Rose Guy et al. JAAD Case Rep. .
No abstract available

Keywords: cancer; generalized pustular psoriasis; metastatic; spesolimab.

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Conflict of interest statement

Dr Duffy has served on an advisory board with Janssen and has been a consultant for Boehringer Ingelheim (2 years after the patient was treated). Drs Kirtani, DeVore, and Guy have no conflicts of interest to declare.

Figures

Fig 1
Fig 1
Initial presentation, progression, and resolution of GPP in a patient with metastatic colon cancer treated with one infusion of spesolimab. A, Initial presentation of his breakthrough GPP. B, Progression to widespread erythroderma just prior to spesolimab infusion. C, Approximately ∼90% clearance of his GPP 4 days post-spesolimab infusion. D, Approximately 100% clearance of his GPP 7 days post-spesolimab infusion. GPP, Generalized pustular psoriasis.
Fig 2
Fig 2
Pathology specimen exhibited mild hyperkeratosis, focal scale crust with neutrophils, irregular epidermal hyperplasia, multifocal intracorneal, and intraepidermal spongiform. Pustules contain neutrophils, acantholytic keratinocytes, and cell debris. Spongiosis with extensive neutrophilic exocytosis, focal early acantholysis, edema of the papillary and superficial reticular dermis, dilated vessels, focal extravasated erythrocytes, and numerous superficial and deep perivascular and interstitial pigment-laden macrophages. Moderately dense superficial and mid-dermal perivascular with interstitial mixed inflammatory infiltrates of neutrophils, histiocytes, lymphocytes, and occasional eosinophils and plasma cells.
See this image and copyright information in PMC

References

    1. Marrakchi S., Puig L. Pathophysiology of generalized pustular psoriasis. Am J Clin Dermatol. 2022;23(Suppl 1):13–19. doi: 10.1007/s40257-021-00655-y. - DOI - PMC - PubMed
    1. Wang W.M., Jin H.Z. Biologics in the treatment of pustular psoriasis. Expert Opin Drug Saf. 2020;19(8):969–980. doi: 10.1080/14740338.2020.1785427. - DOI - PubMed
    1. Burden A.D. Spesolimab, an interleukin-36 receptor monoclonal antibody, for the treatment of generalized pustular psoriasis. Expert Rev Clin Immunol. 2023;19(5):473–481. doi: 10.1080/1744666X.2023.2195165. - DOI - PubMed
    1. Blair H.A. Spesolimab: first approval. Drugs. 2022;82(17):1681–1686. doi: 10.1007/s40265-022-01801-4. - DOI - PMC - PubMed
    1. Elewski B.E., Lebwohl M.G., Anadkat M.J., et al. Rapid and sustained improvements in Generalized Pustular Psoriasis Physician Global Assessment scores with spesolimab for treatment of generalized pustular psoriasis flares in the randomized, placebo-controlled Effisayil 1 study. J Am Acad Dermatol. 2023;89(1):36–44. doi: 10.1016/j.jaad.2023.02.040. - DOI - PubMed

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