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. 2024 Nov 1;51(11):e49-e53.
doi: 10.1097/OLQ.0000000000002050. Epub 2024 Jul 22.

New Pathways in Syphilis Vaccine Development

Andy Liu  1 , Lorenzo Giacani, Kelly L Hawley, Caroline E Cameron, Arlene C Seña  2 , Kelika A Konda  3 , Justin D Radolf  4 , Jeffrey D Klausner  1
Affiliations

New Pathways in Syphilis Vaccine Development

Andy Liu et al. Sex Transm Dis. .

Abstract

The New Pathways in Syphilis Vaccine Development meeting was held before the start of the STI & HIV 2023 World Congress as a pre-meeting symposium to highlight recent advances in the development of an effective syphilis vaccine and discuss the challenges still faced by investigators. Internationally renowned public health officials, clinical investigators, and basic researchers from academia, government, and community-based organizations met on July 24, 2023, in Chicago, Illinois. Four speakers discussed key research findings in syphilis vaccine development, which included antigen selection, identification of epitopes associated with protective immunity, and delivery platforms, with great emphasis on development of chimeric antigens. Significant progress was also shown on the elucidation of Treponema pallidum genomes from virtually all continents to assess the diversity in vaccine candidates of the syphilis spirochete.

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Conflict of interest statement

Conflict of Interest and Sources of Funding: Studies discussed in this review were supported by grants from the National Institutes of Health, National Institute of Allergy and Infectious Diseases (R01 AI155217, R01 AI139265, and R21 AI173988 to J.D.K., U19 AI144133 to L.G. and C.C., and U19 AI144177 to J.D.R.). Dr. Klausner is an advisor for Direct Diagnostics, LLC.

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