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Comment
. 2024 Aug 7;68(8):e0084724.
doi: 10.1128/aac.00847-24. Epub 2024 Jul 22.

Case Commentary: Extending our therapeutic range against multidrug-resistant Candida

Max W Adelman  1   2   3   4 , David R Andes  5
Affiliations
Comment

Case Commentary: Extending our therapeutic range against multidrug-resistant Candida

Max W Adelman et al. Antimicrob Agents Chemother. .

Abstract

Deep-seated Candida spp. infections may necessitate extended durations of antifungal therapy. Increasing resistance to first-line antifungals threatens the most common options for long-term treatment. In this issue, Ponta et al. (Antimicrob Agents Chemother 68:e00750-24, 2024, https://doi.org/10.1128/aac.00750-24) present cases in which they used rezafungin, a novel long-acting echinocandin antifungal, for extended durations. While excellent clinical evidence supports the short-term safety of rezafungin, these cases demonstrate that rezafungin may additionally have a role in long-term suppressive therapy for antifungal-resistant Candida spp. infections.

Keywords: Candida; antifungal agents; antifungal resistance; antifungal therapy; endocarditis; osteomyelitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Comment on

References

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