Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2024 Jul:8:e2400358.
doi: 10.1200/PO.24.00358.

Biomarkers in Oncology: Complexities in Biomarker-Driven Studies and Statistical Analysis

Hajime Uno  1   2   3 , Miki Horiguchi  1   2   4
Affiliations
Editorial

Biomarkers in Oncology: Complexities in Biomarker-Driven Studies and Statistical Analysis

Hajime Uno et al. JCO Precis Oncol. 2024 Jul.

Abstract

Biomarker-driven trials are key for precision oncology but challenge design and analysis.

PubMed Disclaimer

Comment on

References

    1. Wang J, Yu B, Dou Y, et al. : Biomarker-Driven Oncology Trial Design and Subgroup Characterization: Challenges and Potential Solutions. JCO Precision Oncology: TBD - PubMed
    1. Wasserstein RL, Lazar NA: The ASA Statement on p-Values: Context, Process, and Purpose. The American Statistician, 70(2), 129–133, 2016. 10.1080/00031305.2016.1154108 - DOI
    1. Uno H, Horiguchi M, Hassett MJ: Statistical Test/Estimation Methods Used in Contemporary Phase III Cancer Randomized Controlled Trials with Time-to-Event Outcomes. The Oncologist, 25(2), 91–93, 2020. - PMC - PubMed
    1. Uno H, Claggett B, Tian L, et al. : Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis. J Clin Oncol 32, 2380–2385, 2014. - PMC - PubMed
    1. Horiguchi M, Hassett MJ, Uno H: How do the accrual pattern and follow-up duration affect the hazard ratio estimate when the proportional hazards assumption is violated? The Oncologist, 24(7), 867–871, 2019 - PMC - PubMed

Substances

LinkOut - more resources