Cutting back on overdiagnosis - Occam's Razor and unspecific bone uptakes in PSMA PET

Cristiano Pini^{1

2}, Gaia Ninatti^{3

4}, Fabrizia Gelardi^{1

5}, Martina Sollini^{1

5}, Arturo Chiti^{1

5}

Affiliations

¹ Nuclear Medicine Department, IRCCS San Raffaele Hospital, Milan, Italy.
² School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
³ Nuclear Medicine Department, IRCCS San Raffaele Hospital, Milan, Italy. ninatti.gaia@hsr.it.
⁴ School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. ninatti.gaia@hsr.it.
⁵ Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

Editorial

Cristiano Pini et al. Eur J Nucl Med Mol Imaging. 2024 Oct.

. 2024 Oct;51(12):3765-3766.

doi: 10.1007/s00259-024-06852-1.

Cristiano Pini^{1

2}, Gaia Ninatti^{3

4}, Fabrizia Gelardi^{1

5}, Martina Sollini^{1

5}, Arturo Chiti^{1

5}

¹ Nuclear Medicine Department, IRCCS San Raffaele Hospital, Milan, Italy.
² School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
³ Nuclear Medicine Department, IRCCS San Raffaele Hospital, Milan, Italy. ninatti.gaia@hsr.it.
⁴ School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. ninatti.gaia@hsr.it.
⁵ Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

No abstract available

References

1. Rizzo A, Morbelli S, Albano D, et al. The Homunculus of unspecific bone uptakes associated with PSMA-targeted tracers: a systematic review-based definition. Eur J Nucl Med Mol Imaging. 2024;1–12. https://doi.org/10.1007/S00259-024-06797-5 .
1. Seifert R, Telli T, Opitz M, et al. Unspecific 18F-PSMA-1007 bone uptake evaluated through PSMA-11 PET, bone scanning, and MRI triple validation in patients with biochemical recurrence of prostate Cancer. J Nucl Med. 2023;64:738–43. https://doi.org/10.2967/JNUMED.118.215434 . - DOI - PubMed
1. Woo S, Freedman D, Becker AS, et al. Equivocal bone lesions on PSMA PET/CT: systematic review and meta-analysis on their prevalence and malignancy rate. Clin Transl Imaging. 2024;1–16. https://doi.org/10.1007/S40336-024-00631-6 .
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1. Kroenke M, Mirzoyan L, Horn T, et al. Matched-pair comparison of 68Ga-PSMA-11 and 18F-rhPSMA-7 PET/CT in patients with primary and biochemical recurrence of prostate Cancer: frequency of non-tumor-related uptake and Tumor Positivity. J Nucl Med. 2021;62:1082–8. https://doi.org/10.2967/JNUMED.120.251447 . - DOI - PubMed