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Review
. 2024 Sep;205(3):823-832.
doi: 10.1111/bjh.19657. Epub 2024 Jul 22.

Toward a paradigm shift in prognostication and treatment of early-stage Hodgkin lymphoma

Andrea Gallamini  1 , Andrea Filippi  2   3 , Vincent Camus  4   5 , Theodoros P Vassilakopoulos  6
Affiliations
Review

Toward a paradigm shift in prognostication and treatment of early-stage Hodgkin lymphoma

Andrea Gallamini et al. Br J Haematol. 2024 Sep.

Abstract

Twenty years after the conceptual revolution that occurred in the millennium turnaround upon the introduction of PET/CT in lymphoma staging, restaging, and prognostication, a number of new parameters for PET reading have been proposed: (1) the shift from a qualitative to a semi-quantitative reading for PET reporting, (2) an international consensus on these novel interpretation keys, (3) a standardized and agreed procedure to measure the total metabolic tumour volume (TMTV), and (4) the proposition of new indexes to portray the tumour spread: (D-Max and Total Lesion Surface -TLS). These proved to be very powerful prognosticators, able to revolutionize the traditional Ann Arbor four-stage lymphoma staging. During the 17° Lugano meeting on lymphoma, one main question was asked to experts attending a closed workshop dedicated to new metrics for lymphoma diagnosis, staging, restaging, and prognostication: "Should the traditional 4-stage anatomic staging system be simplified to a more clinically relevant 2-stage system (e.g., limited vs. extensive disease)?" Early-stage HL is an example of how these new metrics could fit with this proposal.

Keywords: Hodgkins lymphoma; PET; early‐stage; prognostic factors.

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References

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